With aging, there is progressive loss of tissue homeostasis and functional reserve, leading to an impaired response to stress and an increased risk of morbidity and mortality. A key mediator of the cellular response to damage and stress is the transcription factor NF-κB. We demonstrated previously that NF-κB transcriptional activity is upregulated in tissues from both natural aged mice and in a...

The Impact of Risk Perception and Risk Attitudes on Corrupt Behavior: Evidence from a Petty Corruption Experiment We investigate one possible explanation for observed rates of corrupt behavior namely that individual decision makers who frequently engage in illegal actions may underestimate the overall probability of being caught. This might in particular be true for petty corruption where small...

The XPF/Mus81 family of structure-specific nucleases cleaves branched or nicked DNA substrates and are implicated in a wide range of DNA repair and recombination processes. The structure of the crenarchaeal XPF bound to a DNA duplex has revealed a plausible mechanism for DNA binding, involving DNA distortion into upstream and downstream duplexes engaged by the two helix-hairpin-helix domains th...

In this study we explore and document perceptions of slum dwellers about causes of poverty and petty corruption in slum areas of Karachi (Pakistan). Moreover, we examine the effects of fatalism on poverty, large family size, and child labor. We conduct a survey by interviewing 100 respondents covering all districts (Central, West, East, Malir, and South) to document slum dwellers’ perceptions. ...

Down syndrome is a rare cause of neonatal cholestasis. Neonatal cholestasis in a patient with Down syndrome is usually associated with severe liver diseases, such as neonatal hemochromatosis, myeloproliferative disorder and intrahepatic bile duct paucity. We experienced a case of idiopathic neonatal cholestasis in a patient with Down syndrome, which resolved spontaneously. (Pediatr Gastroentero...

OBJECTIVE To estimate the effect of maternal illicit and prescription drug use on neonates in Washington State between 2000 and 2008. METHODS We used state-linked birth certificate and hospital discharge (mother and neonate) data to calculate prenatal drug exposure and neonatal abstinence syndrome rates, and compared state neonatal abstinence syndrome rates with national-level data from the N...

This paper analyses mechanisms underlying firm’s compliance with environmental regulations. By using a political economy approach through a Principal-Agent model, we examine how the dynamic of environmental compliance could affect governance infrastructures by shaping the structure of institutional incentives related to stakeholder’s behaviors in regulation process. Taking the case of deforesta...

The norm defined by Busemann’s inequality establishes a class of star body intersection body. This class of star body plays a key role in the solution of Busemann-Petty problem. In 2003, Giannapoulos [1] defined a norm for a new class of half-section. Based on this norm, we give a geometric generalization of Busemann-Petty problem, and get its answer as a result.