Aim: Primary aim of this study is to compare the neonatal and maternal complications women with Gestational Diabetes Mellitus (GDM) treated insulin or followed by diet. Secondary evaluate rate cesarean section indications that.
 Methods: Women GDM were divided into two groups as (n=110) diet (n=200). Demographic data, antenatal follow-up measurements, gestational week at birth type deliver...

Neonatal diabetes mellitus (NDM) is a rare manifestation with an incidence of one affected individual among 400000 live births. NDM can be divided into Transient (TNDM) and Permanent (PNDM) types. A significant overlap occurs between both groups, to an extent that TNDM cannot be distinguished from PNDM based solely on clinical features. Diabetic ketoacidosis (DKA) is the leading cause of morbid...

Masaki Takagi1, 2, Ryojun Takeda3, Hiroko Yagi4, Daisuke Ariyasu5, Ryuji Fukuzawa2, and Tomonobu Hasegawa1 1 Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan 2 Department of Pathology and Laboratory Medicine, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 3 Department of Medical Genetics, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 4 Departme...

background: reported data from developed countries showed that annually a high percentage of health budgets consume for controlling and treatment of complications in diabetes disease. early diagnosis of diabetes, education and health cares, not only prevent progress of disease and complications but also it is cost effective. methods: for gestational diabetes screening, all pregnant women attend...

OBJECTIVE Permanent neonatal diabetes (PND) is defined by chronic hyperglycemia due to severe nonautoimmune insulin deficiency diagnosed in the first months of life. Several genes, including KCNJ11 and ABCC8, which encode the two subunits of the ATP-sensitive K(+) channel (K(ATP) channel) can cause PND. Mutations in the insulin (INS) gene have been recently described in families with neonatal d...

background this study evaluates the frequency of diabetes complication in infants of diabetic mothers (idms), and investigates its relationship with patients’ follow-up care and maternal glucose control. material and methods diabetic mothers who delivered in ahvaz imam khomeini hospital in 2011 were given questionnaires to gather data on gender of infants, gestational age, type of diabetes (ove...

Insulin (INS) gene mutations that cause permanent neonatal diabetes mellitus change single protein building blocks (amino acids) in the protein sequence. These mutations are believed to disrupt the cleavage of the proinsulin chain or the binding of the A and B chains to form insulin, leading to impaired blood sugar control. At least 10 mutations in the INS gene have been identified in people wi...

934 www.thelancet.com Vol 386 September 5, 2015 Diabetes is a lifelong chronic disease. During the past 100 years, its diagnosis has been based on measurements of raised blood glucose concentrations. In the 1960s, diabetes was subclassifi ed based on age at onset and need for insulin treatment (ie, juvenile or maturity onset; insulin or non-insulinrequiring diabetes). Because diabetes was belie...

Neonatal diabetes mellitus is considered a rare disease that is diagnosed in the first six months of life, and can be either transient or permanent. Recent advances in molecular genetics have shown that activating mutations in KCNJ11 (the gene that encodes for the Kir6.2 subunit of the K ATP potassium channel of the pancreatic beta-cell) is a common cause of permanent neonatal diabetes mellitus...