Amyloid beta-peptide (Abeta) is generated by the consecutive cleavages of beta- and gamma-secretase. The intramembraneous gamma-secretase cleavage critically depends on the activity of presenilins (PS1 and PS2). Although there is evidence that PSs are aspartyl proteases with gamma-secretase activity, it remains controversial whether their subcellular localization overlaps with the cellular site...

BACKGROUND Oxygenation via the cricothyroid membrane (CTM) may be required in emergencies, but inadvertent tracheal cannulation may occur. In this study, we compared airway injury between the tracheal and CTM sites using different techniques for airway access. METHODS Anesthesiologists performed 4 airway access techniques on excised porcine tracheas. The techniques were 1) wire-guided (WGT), ...

Facial gingival tissue thickness (FGTT) is important for an esthetically pleasing anterior restoration since it determines the soft tissue's ability to conceal the underlying restorative material. The purpose of this study was to investigate the change in FGTT after immediate implant placement and provisionalization with and without a connective tissue graft. Patients with a failing maxillary a...

Methods We carried out a SR of advanced prostate cancer (PC) trials published over the period 2008-2013 (reported separately) and then reviewed the corresponding trials registry entries for the studies included in the SR. Clinicaltrials.gov NCT registration numbers were extracted from the papers where available. Where an NCT number was not available, the registry was searched for the study. A t...

We summarize previous researches regarding neutron guides of small transverse cross-section (neutron fibres), smaller than those of the standard hollow guides and collimators employed currently. Those studies may not be widely known in the neutron capture therapy (NCT) community, but they may be interesting for it. Such neutron fibres could allow to deliver and concentrate neutron beams selecti...

Nowadays neutron capture therapy looks very promising method of cancer treatment, especially for brain tumors by reason of selective damage cancer cells. Treatment effect of this method based on neutrons nuclear reaction with nuclides B, Gd. These nuclides have high cross-section of interaction with thermal neutrons. Unfortunately, thermal neutrons could enter only in near surface tissue and co...

Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent diarrhea-inducing properties. We have constructed two CT-A subunit mutants, e.g., serine-->phenylalanine at position 61 (S61F), and glutamic acid-->lysine at 112 (E112K) by site-directed mutagenesis. Neither mutant CT (mCT), in contrast to native CT (nCT), induced aden...

The aim of this study was to investigate the potential of progesterone receptor (PgR) as a biomarker for differentiating estrogen receptor (ER)-positive patients who fail to achieve a pathological complete response to neoadjuvant chemotherapy (NCT) with different prognoses. A total of 327 consecutive, locally advanced breast cancer patients with ER-positive disease were included in this study. ...

INTRODUCTION This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements. METHODS This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years ...