Skeletal involvement is the second most common site of metastases after lymph nodal metastases in patients with prostate cancer. The skeletal metastases from prostate cancer are osteoblastic in nature and show increased tracer avidity on the bone scan. Focal tracer avid lesion in skeleton especially in skull requires the careful examination by further investigation. The patients with skull meta...

Nature and nurture interact and in most cases it is impossible to specify quantitatively the contribution of either to the causation of a disease. Only rarely is either neutral in the sense that the other accounts for all the variation in risk. It seems unlikely that more than a few per cent of all cancers will be accounted for by inherited susceptibility with a high penetrance and a neutral en...

Background Endometrial cancer is a hormone-dependent disease and has been consistently associated with obesity. Non genetic lifestyle factors may account for more than 75% of endometrial cancer cases and represent potential targets for prevention of this disease. Insulin resistance induced by diet may play a particularly pernicious role in the development of endometrial cancer, possibly by redu...

Anal cancer is rare, accounting for about 2% of all anorectal cancers or 300 cases a year in Britain.' Epidemiological studies from the United States have highlighted the striking association of syphilis and anal warts with anal cancer in unmarried men.23 Gonorrhoea, syphilis, and anal warts are more common in homosexual than heterosexual men,4 and carcinoma in situ may develop in the anal wart...

background: north of iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds especially agricultural pesticides are massively used. cytochrome p450 2e1 (cyp2e1) enzyme metabolically activates a large number of low molecular mass xenobiotics. the polymorphic nature of cyp2e1 gene control elements is associated with interindividual differences for...