The relationship between intensity of inflammatory stimulation and production of α(2)-macroglobulin (α2M) and α(1)-acid glycoprotein (AAG) in rats was investigated. Sprague-Dawley rats were injected with turpentine oil at doses of 0.05, 0.2 or 0.4 mL/rat. Serum levels of α2M, interleukin (IL)-6 and cytokine-induced neutrophil chemoattractant-1 (CINC-1) were measured by enzyme-linked immunosorbe...

To determine the cell of origin of C-reactive protein (CRP) and to cast light on the mechanisms leading to the acute phase response, we used an immunoenzymatic technique to visualize this protein in livers from rabbits at intervals after intramuscular injection of turpentine. CRP was detected only in hepatocytes. 8 h after turpentine injection, CRP was demonstrated in occasional periportal hepa...

Kozak, Wieslaw, and Anna Kozak. Selected Contribution: Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nos gene-deficient mice. J Appl Physiol 94: 2534–2544, 2003. First published January 31, 2003; 10.1152/japplphysiol.01042.2002.—Male C57BL/6J mice deficient in nitric oxide synthase (NOS) genes (knockout) and control (wild-type) mice were imp...

Ram Golam, Chamar cooly, aged 43, was admitted on the 23rd June, 1865, with the following symptoms Abdomen tympanitic, considerably swollen, and slightly painful; tongue moist, with a yellow fur in the centre ; pulse feeble ; countenance anxious ; skin cool. States that the bowels have been confined for seven days, and that all this time he lias had pain in the belly. He has taken quantities of...

IL-6 and TNFa have been shown as important cytokines in liver regeneration induced in partially hepatectomized rats. Nonetheless, IL-6 gene expression in the course of chemically induced hepatic regeneration, resembling what occurs in humans infected by hepatitis virus in acute manner, remains obscure. To gain an insight on this matter we determined IL-6 and TNFa gene expression in Wistar rats ...

Turpentine oil, owing to the presence of 7–50 terpenes, has analgesic, anti-inflammatory, immunomodulatory, antibacterial, anticoagulant, antioxidant, and antitumor properties, which are important for medical emulsion preparation. The addition turpentine oil squalene emulsions can increase their effectiveness, thereby reducing concentration expensive possibly deficient squalene, increasing its ...