Despite the considerable advances in our understanding of biological processes, the physicochemical relationship between living and nonliving systems remains uncertain and a continuing source of controversy. In this review, we describe a kinetic model based on the concept of dynamic kinetic stability that attempts to incorporate living systems within a conventional physicochemical framework. It...

Charles Darwin noted that natural selection applies even to the hourly organization of daily life. Indeed, in many species, the day is segmented into active periods when the animal searches for food, and inactive periods when the animal digests and rests. This episodic temporal patterning is conventionally referred to as ultradian (<24 hours) rhythmicity. The average time between ultradian even...

Flies of the genus Drosophila, and particularly those of the species Drosophila melanogaster, are best known as laboratory organisms. As with all model organisms, they were domesticated for empirical studies, but they also continue to exist as wild populations. Decades of research on these flies in the laboratory have produced astounding and important insights into basic biological processes, b...

We present a formal language for specifying distributed authorization policies that communicate through insecure asynchronous media. The language allows us to write declarative authorization policies; the interface between policy decisions and communication events can be specified using guards and policy updates. The attacker, who controls the communication media, is modeled as a message deduct...

Continuous-time, multistate processes can be used to represent a variety of biological processes in the public health sciences; yet the analysis of such processes is complex when they are observed only at a limited number of time points. Inference methods for such panel data have been developed for time homogeneous Markov models, but there has been little research done for other classes of proc...

Phenotype-based small molecule screens in zebrafish embryos and larvae have been successful in accelerating pathway and therapeutic discovery for diverse biological processes. Yet, the application of chemical screens to adult physiologies has been relatively limited due to additional demands on cost, space, and labor associated with screens in adult animals. In this study, we present a 3D print...

In this paper we argue that sequent proofs systems are a better deductive apparatus for introducing proofs to students than are natural deduction systems. Natural deduction derivations of superintuitionistic theorems (theorems of classical logic that are not intuitionistically valid) require indirect and often obtuse constructions. Constructing derivations in sequent systems is uniform, driven ...

social learning and knowledge generation are two key factors to achieve successful natural resources co-management. social learning can be beneficial by broadcasting and transmitting experiences and problem solving ideas in a group of people. social learning networks can transmit knowledge and experiences from one node to another in the network. social learning can produce a suitable learning a...

To develop new strategies for searching for genetic associations with complex human diseases, we analyzed 2784 single-nucleotide polymorphisms (SNPs) in 396 protein-coding genes involved in biological processes relevant to cancer and other complex diseases, with respect to gene diversity within samples of individuals representing the three major historic human populations (African, European, an...

In recent years, marine natural product bioprospecting has yielded a considerable number of drug candidates. Most of these molecules are still in preclinical or early clinical development but some are already on the market, such as cytarabine, or are predicted to be approved soon, such as ET743 (Yondelis). Research into the ecology of marine natural products has shown that many of these compoun...