Background: Diabetes mellitus is a comorbid disease that greatly interferes with the process of wound healing, including injuries to gingival tissue. The Aloe vera plant, or vera, one Indonesia's natural wealth, which often found and has been widely used by community in overcoming various health problems, treat wounds. This study aims explore potential hydrogen acemannan repair tissue rats diab...

Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical and degradation properties. In this study, a photocrosslinkable gelatin (i.e., gelatin methacrylamide (GelMA...

In the year 2000 a new rapid prototyping (RP) technology was developed at the Freiburg Materials Research Center to meet the demands for desktop fabrication of scaffolds useful in tissue engineering. A key feature of this RP technology is the three-dimensional (3D) dispensing of liquids and pastes in liquid media. In contrast to conventional RP systems, mainly focused on melt processing, the 3D...

A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21,...

Current strategies to improve wound healing are often created from multiple components that may include a scaffold, cells, and bioactive cues. Acellular natural hydrogels are an attractive approach since the material's intrinsic biological activity can be paired with mechanical properties similar to soft tissue to induce a host's response toward healing. In this report, a systematic evaluation ...

We report lipase-catalyzed inclusion of p-hydroxy benzylalcohol to peptide bolaamphiphiles. The lipase-catalyzed reactions of peptide bolaamphiphiles with p-hydroxy benzylalcohol generate dynamic combinatorial libraries (DCL) in aqueous medium that mimic the natural dissipative system. The peptide bolaamphiphile 1 (HO-WY-Suc-YW-OH) reacts with p-hydroxy benzylalcohol in the presence of lipase f...

Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of anti-adhesion drug. Dexamethasone (Dex) was encapsulated in polymeric micelles (Dex micelles), and then the Dex micelles were loaded into biodegradabl...

Abstract Introduction Cardiovascular diseases are a main cause of death globally, and their treatment implies various vascular repairs through different techniques like angioplasty, stent placement in the blocked artery, or bypass surgery. Artificial grafts would significantly reduce number non-treated patients, but middle long-term failures compromise clinical use. Methods Herein, we developed...

Polymer blending is a simple yet attractive method to obtain combined physical and mechanical properties of polymers. In this paper, three types of blend hydrogels were prepared, each by physically blending two different natural polymers, and a model drug, theophylline (TPH), was immobilized into these hydrogels for the studies of drug release. The release profiles of TPH from various types of ...