Naphthalene (NA) is metabolized to highly reactive intermediates that are primarily detoxified by conjugation to glutathione (GSH). Intraperitoneal administration of naphthalene causes substantial loss of both hepatic and respiratory GSH, yet only respiratory tissues are injured in mice. The liver supplies GSH to other organs via the circulation, making it unclear whether respiratory GSH losses...

Naphthalene AA-Final, a naphthalene preparation, is a new tool in the management of psoriasis. Brown naphthalene has been used for 15 years in the treatment of psoriasis at Special Hospital for Medical Rehabilitation in Ivanic Grad, Croatia. Naphthalene is obtained from naphtha, a complex mixture of various compounds, mostly hydrocarbons. Naphthalene AA-Final is a new naphthalene preparation en...

The formation of hydrogen bonded complexes between nucleic acid bases and acetamide has been studied by nuclear magnetic resonance in CDC13 at different temperatures. Pairs of hydrogen bonds are formed when acetamide binds to nucleic acid bases. Thermodynamic parameters have been computed and compared to those obtained for the association of carboxylic acids with nucleic acid bases. The role of...

Five patients with various malignant diseases excreted rapidly, chiefly in the urine, isotope from a single oral tracer dose of ./V-2-fluorenyl-9-C14-acetamide. The urine con tained 24-30 per cent of the dose of the detoxification product, ^-(T-hydroxy^-fluorenyl)acetamide, as the glucuronic acid conjugate. The other major metabolite was Af-hydroxy-2-fluorenylacetamide, a proximate carcinogen d...

We characterized the biosynthesis of indole-3-acetic acid by the mycoherbicide Colletotrichum gloeosporioides f. sp. aeschynomene. Auxin production was tryptophan dependent. Compounds from the indole-3-acetamide and indole-3-pyruvic acid pathways were detected in culture filtrates. Feeding experiments and in vitro assay confirmed the presence of both pathways. Indole-3-acetamide was the major p...

The molecular structures of the three conformers of acetamide are first studied by ab initio method of CCSD/cc-pVTZ. Using the optimized geometry of each species, we apply established and/or developing methods to compute several physical properties of acetamide and compare them with available experimental data. The properties include dipole moments, polarizabilities, ionization energies of both...

Previous studies have shown variability in naphthalene cytotoxicity, expression of CYP2F2 gene and protein, and naphthalene metabolism in random cycling female mice (NIH:Swiss). CYP2F2 metabolizes naphthalene to cytotoxic metabolites in lungs of mice. This study was designed to address the question: do hormonal changes associated with the estrous cycle alter metabolism of naphthalene in the lun...

Previous studies have shown variability in naphthalene cytotoxicity, expression of CYP2F2 gene and protein, and naphthalene metabolism in random cycling female mice (NIH:Swiss). CYP2F2 metabolizes naphthalene to cytotoxic metabolites in lungs of mice. This study was designed to address the question: do hormonal changes associated with the estrous cycle alter metabolism of naphthalene in the lun...

Previous studies have shown variability in naphthalene cytotoxicity, expression of CYP2F2 gene and protein, and naphthalene metabolism in random cycling female mice (NIH:Swiss). CYP2F2 metabolizes naphthalene to cytotoxic metabolites in lungs of mice. This study was designed to address the question: do hormonal changes associated with the estrous cycle alter metabolism of naphthalene in the lun...

Naphthalene, a constituent of coal tar, is a contaminant frequently found at former manufactured gas plants (MGP). Development at these sites has resulted in residential and commercial areas with potential exposures from vapor intrusion adversely affecting indoor air of residences and buildings. Naphthalene is routinely analyzed in soil vapor intrusion assessments for properties overlying and s...