Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were prepared by high shear homogenization and characterized by size, polydispersity index, zeta potential, morphology and physical stability. Occlusive effect was assessed by an in vitr...

Most of the new chemical entities discovered today are highly lipophilic in nature and show poor solubility and membrane permeability resulting in poor oral bioavailability. The need for an effective carrier system led to the development of novel lipid based carriers for enhancing the solubility and bioavailability of such drugs Lipids are fatty acids and their derivatives, and substances relat...

Therapeutic proteins are well-tolerated bioactive compounds used in different therapies, due to its high specificity and biopotency. Nevertheless, they may also present some physicochemical instability, leading loss of bioactivity hampering treatments. This can be avoided by loading into lipid nanoparticles, which biocompatible biodegradable carriers. The use lipids nanoparticles deliver therap...