BACKGROUND We have developed a silicon-based biosensor that generates a visual signal in response to nucleic acid targets. METHODS In this system, capture oligonucleotide probes are immobilized on the surface of the biosensor. Interaction of the capture probes with a complementary target and a biotinylated detector oligonucleotide allows initiation of formation of an organic thin film on the ...

We present a novel plasmonic antenna structure, a split-wedge antenna, created by splitting an ultrasharp metallic wedge with a nanogap perpendicular to its apex. The nanogap can tightly confine gap plasmons and boost the local optical field intensity in and around these opposing metallic wedge tips. This three-dimensional split-wedge antenna integrates the key features of nanogaps and sharp ti...

Efficient frequency conversion techniques are crucial to the development of plasmonic metasurfaces for information processing and signal modulation. In principle, nanoscale electric-field confinement in nonlinear materials enables higher harmonic conversion efficiencies per unit volume than those attainable in bulk materials. Here we demonstrate efficient second-harmonic generation (SHG) in a s...

Field-effect transistor (FET)-type biosensors have shown potential for use in label-free electrical detection with high sensitivity. An ion-selective FET (ISFET) utilizes a reference electrode in the form of an aqueous solution. Its conductance is dependent on charged species on the surface of the ISFET. The sensitivity of nanowire FETs (NWFETs) is high enough to enable single-molecule detectio...

The fabrication of galactose biosensor based on functionalised ZnO nanorods is described. The galactose biosensor was developed by immobilizing galactose oxidase on ZnO nanorods in conjunction with glutaraldehyde as a cross-linker molecule. The IRAS study provided evidence for the interaction of galactose oxidase with the surface of ZnO nanorods. The electromotive force (EMF) response of the ga...

The response of an amperometric biosensor based on a chemically modified electrode was modelled numerically. A mathematical model of the biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments: an enzyme layer and an outer diffusion layer. In order to define the main governing parameters the corresponding dimensionless mathem...

McGoron A.J., Research Guide Professor Email: [email protected] Phone: +1-305-348-1352 Abstract The detection, identification and monitoring of chemical and biological toxins (CBTs) released during warfare and disaster into the environment has critical global importance. The aim of this review article is to give a clear picture of the trend in the development of biosensor technologies for the de...

Over the last several decades, a great number of advances have been made in the area of self-assembled supramolecules for regenerative medicine. Such advances have involved the design, preparation, and characterization of brand new self-assembled peptide nanomaterials for a variety of applications. Among all biomolecules considered for self-assembly applications, peptides have attracted a great...