A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly water-soluble drug docetaxel. DTX-TPGS-PN niosomes were 93 ± 6.5 nm in size, -18.53 ± 1.65 mV in zeta potential and exhibited spherical morphology, with an encapsulation efficiency of 97.31 ± 0.60%. The system showed susta...

Our previous study demonstrated the potent in vitro collagen biosynthesis stimulating and antioxidant activities of Volvariella volvacea extract. This study was performed the loading of V. volvacea extract (VV) in niosomes (NV). The physicochemical characterization of the VV loaded niosomes and gel containing niosome of the extract (GNV) was studied. Rat skin transdermal absorption by Franz dif...

Over the past years the treatments of disease have undergone a revolutionary change. With the advancement of pharmaceutical science not only novel drug delivery system have been developed but also emphasis has been laid to deliver the active constituent to the diseased site.The basic component of such a system is a suitable carrier that protects the active medicament from degradation or clearan...

OBJECTIVE The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging ...

BACKGROUND Propolis is a multicomponent active, complex resinous substance collected by honeybees (Apis mellifera) from a variety of plant sources. This study was designed to improve the antimicrobial efficacy of propolis by engineering a niosomal-based system for topical application. METHODS Propolis was extracted in ethanol and screened for total polyphenol content. Propolis-loaded niosomes...

the aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. three independent variables selected were molar ratio of drug to lipid (x1), surfactant loading (x2) and volume of hydration (x3). based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

objective(s): the purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. materials and methods: niosomes were prepared by thin film hydration (tfh) or hand shaking (hs) method. propranolol niosomes were pre...

Niosomes, non-ionic surfactant vesicles (NSVs), are the hydrated lipids composed mainly of different classes of non-ionic surfactants, introduced in the seventies as a cosmetic vehicle. Nowadays, niosomes are used as important new drug delivery systems by many research groups and also they are effective immunoadjuvants which some commercial forms are available in the market. These vesicles rece...