The central nervous system disorders represent a worldwide public health problem. Neuro-degeneration is associated with many transitions in brain including synaptic disorder and neuro-cognition decline. It shielded by barrier which controls the entry of compounds into known as blood (BBB), there regulating homeostasis. In achieving therapeutic amount drug to proper site action body then maintai...

AIMS To determine how the accumulation of drug in mice bearing an extra-hepatic tumor and its therapeutic efficacy are affected by the type of PEGylated liposomal doxorubicin used, treatment modality, and rate of drug release from the liposomes, when combined with radiofrequency (RF) ablation. MATERIALS AND METHODS Two nano-drugs, both long-circulating PEGylated doxorubicin liposomes, were fo...

Targeted drug-delivery systems are used for the administration of pharmaceutical medicament enables localization drugs to diseased sites. Different types uses carriers, like immunoglobulins, serum proteins, synthetic polymers, liposomes, nanoparticle and microspheres. Niosomes an emerging type novel vesicular systems. Now they being fervent explored as potential carriers targeted drug delivery....

the nasal cavity possesses many advantages as a site for drug delivery, such as, ease of administration, applicability for long term treatments and a large surface area for absorption. one important limiting factor for nasal drug delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. several drug delivery systems including different kinds of ...

Nano-drug delivery systems have several advantages compared to the traditional forms of drugs. A nanocarrier sytem transport the drug to the site of action, hence, its influence on vital tissues and undesirable side effects can be minimized. Accumulation of therapeutic compounds in the target site increases and, consequently, the required doses of drugs are lower. Cell-specific targeting can be...

Recent progress in understanding the molecular structures and mechanisms of action of proton pumps has paved the way to their novel applications in biotechnology. Proton pumps, bacteriorhodopsin and ATP synthases in particular, are capable of continuous, renewable conversion of light to chemical, mechanical or electrical energy, which can be used in macro- or nano-scale devices. The capability ...

The formulation and evaluation of diclofenac sodium from liposomes, niosomes and nanoemulsion are analyzed. The release profiles of diclofenac sodium were almost similar in all the formulations. It is found that 85% of diclofenac sodium diffused out from the colloidal systems within 8hrs and practically all the drug was released within 12hrs. In addition to this controlled release, the similari...

Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physic...

The lipid bilayer of model membranes, liposomes reconstituted from cell lipids, and plasma membrane vesicles and spheres can separate into two distinct liquid phases to yield lipid domains with liquid-ordered and liquid-disordered properties. These observations are the basis of the lipid raft hypothesis that postulates the existence of cholesterol-enriched ordered-phase lipid domains in cell me...