For drug delivery, characterization of liposomes regarding size, particle number concentrations, occurrence of low-sized liposome artefacts and drug encapsulation are of importance to understand their pharmacodynamic properties. In our study, we aimed to demonstrate the applicability of nano Electrospray Gas-Phase Electrophoretic Mobility Molecular Analyser (nES GEMMA) as a suitable technique f...

ABSTRACT Fungal infections of the central nervous system (CNS) usually present as subacute meningitis or intracranial space occupying lesion with mass effect on surrounding structures and consequent focal neurological deficits. Intracranial fungal granulomas are often misdiagnosed clinically and radiologically as neoplastic lesions.  Biopsy of the lesion is the only reliable technique to estab...

An elusive goal for systemic drug delivery is to provide both spatial and temporal control of drug release. Liposomes have been evaluated as drug delivery vehicles for decades, but their clinical significance has been limited by slow release or poor availability of the encapsulated drug. Here we show that near-complete liposome release can be initiated within seconds by irradiating hollow gold ...

Emergent Coronaviridae viruses, such as SARS-CoV-1 in 2003, MERS-CoV 2012, and SARS-CoV-2 (CoV-2) 2019, have caused millions of deaths. These viruses added to the existing respiratory infection burden along with syncytial virus (RSV) influenza. There are limited therapies for broad-spectrum treatment remaining an unmet need. Since gut fermentation fiber produces short-chain fatty acids (SCFA) a...

in this work, the characteristics of flow and heat transfer of a fluid containing nano particles of aluminum oxide with the water volume fraction (0.1-0.2-0.3)(v/v) percent of the reports. the overall heat transfer coefficient, heat transfer and the average heat transfer fluid containing nano water - aluminum oxide in a horizontal double pipe counter flow heat exchanger under turbulent flow con...

Liposomes are artificially prepared vesicles consisting of natural and synthetic phospholipids that are widely used as a cell membrane mimicking platform to study protein-protein and protein-lipid interactions, monitor drug delivery, and encapsulation. Phospholipids naturally create curved lipid bilayers, distinguishing itself from a micelle. Liposomes are traditionally classified by size and n...

The kinetics of activation of tumoricidal functions in mouse macrophages incubated with macrophage-activating factors (MAF) released by mitogen-stimulated lymphocytes (free MAF) and MAF encapsulated with liposomes (liposome-MAF) have been compared. Development of tumoricidal activity requires incubation of macrophages with free or liposome-encapsulated MAF for a minimum of 4 hr. Macrophages inc...

The short-lived peptide, angiotensin-(1-7) (Ang-(1-7)), was encapsulated in different liposome preparations, in order to evaluate the influence of membrane fluidity, membrane surface, liposome size and dose of peptide on the cardiovascular effects of the encapsulated peptide at a specific site of the brain. These preparations were microinjected unilaterally into the rostral ventrolateral medull...

Patients with impaired immunity are at particular risk of infections with Candida albicans. Antifungal drugs such as azoles commonly used for candidiasis treatment, but drug resistance is one of the most common problems for public health. The aim of this study was to evaluate the expression of lanosterol 14-demethylase (ERG11) gene for three-drug combinations in C. albicans. Disk diffusion and ...