Attacks on the cyber space is getting exponential in recent times. Illegal penetrations and breaches are real threats to individuals organizations. Conventional security systems good enough detect known but when it comes Advanced Persistent Threats (APTs) they fails. These APTs targeted, more sophisticated very persistent incorporates lot of evasive techniques bypass existing defenses. Hence, t...

Multi-electron dynamics in atoms and molecules very often occur on sub- to few-femtosecond time scales. The available intensities of extreme-ultraviolet (XUV) attosecond pulses have previously allowed the time-resolved investigation two-photon, two-electron interactions. Here we study double triple ionization argon involving absorption up five XUV photons using a pair intense pulse trains (APTs...

Nanoparticles (NPs) may affect the lung via their chemical composition on the surface. Here, we compared the bioactivity of zirconium oxide (ZrO₂) NPs coated with either aminopropilsilane (APTS), tetraoxidecanoic acid (TODS), polyethyleneglycol (PGA), or acrylic acid (Acryl). Supernatants from NPs-treated cultured alveolar macrophages (NR8383) tested for lactate dehydrogenase, glucuronidase, tu...

Google’s software update system can serve as a model Advanced Persistent Threat (APT). APTs often embed programs in a penetrated system. These programs wake up from time to time, call home, download additional programs and instructions to carry out, and modify systems. Google’s software update performs all these steps too. Furthermore, because the Google Chrome browser is so widely used and upd...

A major cause of implant failure in skeletal tissues is failure of osseointegration, often due to lack of adhesion of cells to the titanium (Ti) alloy interface. Since arginine-glycine-aspartic acid (RGD)-containing peptides have been shown to regulate osteoblast adhesion, we tested the hypothesis that, bound to a Ti surface, these peptides would promote osteoblasts differentiation, while at th...

Developing a detailed threat profile, provides organizations with a clear illustration of the threats that they face, and enables them to implement a proactive incident management program that focuses on the threat component of risk. Organizations are facing new types of advanced persistent threat (APT) scenarios that existing risk management programs are not able to evaluate completely and inc...

The emergence of the occipital alpha rhythm on brain electroencephalogram (EEG) is associated with brain activity in the cerebral neocortex and deep brain structures. To further understand the mechanisms of alpha rhythm power fluctuation, we performed simultaneous EEGs and functional magnetic resonance imaging recordings in human subjects during a resting state and explored the dynamic relation...

The Fc glycosylation of therapeutic antibodies is crucial for their effector functions and their behavior in pharmacokinetics and pharmacodynamics. To monitor the Fc glycosylation in bioprocess development and characterization,high-throughput techniques for glycosylation analysis are needed. Here, we describe the development of a largely automated high-throughput glycosylation profiling method ...

The Newark-APTS established a high-resolution framework for the Late Triassic and Early Jurassic. Palaeomagnetic polarity correlations to marine sections show that stage-level correlations of continental sequences were off by as much as 10 million years. New U–Pb ages show the new correlations and the Newark basin astrochronology to be accurate. Correlation of Newark-APTS to the Chinle Formatio...

High-throughput methods for oligosaccharide analysis are required when searching for glycan-based biomarkers. Next to mass spectrometry-based methods, which allow fast and reproducible analysis of such compounds, further separation-based techniques are needed, which allow for quantitative analysis. Here, an optimized sample preparation method for N-glycan-profiling by multiplexed capillary gel ...