background:   objective: present study was conducted to observe the effects of testosterone, nandrolone, and stanozolol (forms of aas) intake during onset of puberty on the rat testicular histology.   materials and methods: juvenile male sprague-dawley (sd) rats (n=42) were divided into seven groups and were injected subcutaneously with medium dose of polyethylene glycol-200 (peg-200) (control)...

background: most studies on anabolic-androgenic steroids abuse have been done in adult rats, but few data are available to immature. objective: this study was conducted to assay the effect of nandrolone decanoate (nd) on the testis and testosterone concentration in male immature rats compare with mature ones in short and long time. materials and methods: 40 mature rats were divided into 4 group...

Background: To improve the athletic ability and muscle mass, anabolic androgenic steroids are abused by athletes. Little is known about how these compounds affect the fine structures of the testis. This study aimed to identify the changes in the fine structure of testis following administration of nandrolone decanoate. Methods: Twenty five Sprague-Dawley rats were randomly divided into two expe...

background: to improve the athletic ability and muscle mass, anabolic androgenic steroids are abused by athletes. little is known about how these compounds affect the fine structures of the testis. this study aimed to identify the changes in the fine structure of testis following administration of nandrolone decanoate.   methods: twenty five sprague-dawley rats were randomly divided into two ex...

OBJECTIVE To investigate the effectiveness of a body mass reduction programme entailing diet caloric restriction and moderate physical activity with or without supplementary treatment with recombinant (r) GH or steroids to improve body composition and muscle performance in severely obese women aged 61-75 years. METHODS Twenty women were randomly assigned to one of three groups: body mass redu...

Involvement of intracellular Ca(2+) and ERK1/2 phosphorylation in the fast nongenomic effects of androgens in myotubes was investigated. Testosterone or nandrolone produced fast (<1 min) and transient increases in intracellular Ca(2+) with an oscillatory pattern. Calcium signals were slightly reduced in Ca(2+)-free medium, but lack of oscillations was evident. Signals were blocked by U-73122 an...

BACKGROUND To date, no studies document the effect of anabolic steroids on rotator cuff tendons. STUDY DESIGN Controlled laboratory study. HYPOTHESIS Anabolic steroids enhance remodeling and improve the biomechanical properties of bioartificially engineered human supraspinatus tendons. METHODS Bioartificial tendons were treated with either nandrolone decanoate (nonload, steroid, n = 18), ...

Current data suggest that the use of anabolic androgenic steroids (AAS) has become quite common among athletes, bodybuilders, as well as adolescents and young adults who want to increase their muscle mass for aesthetic or athletic reasons. Commonly used anabolic steroids are the oral 17a alkyl derivatives of testosterone (methyl testosterone, oxymetholone, oxandrolone, stanozolol) and the intra...

This study describes development and subsequent validation of a reversed phase high performance liquid chromatographic (RP-HPLC) method for the estimation of nandrolone phenylpropionate, an anabolic steroid, in bulk drug, in conventional parenteral dosage formulation and in prepared nanoparticle dosage form. The chromatographic system consisted of a Luna Phenomenex, CN (250 mm x 4.6 mm, 5 micro...