The Charm++ parallel programming system provides a modular performance interface that can be used to extend its performance measurement and analysis capabilities. The interface exposes execution events of interest representing Charm++ scheduling operations, application methods/routines, and communication events for observation by alternative performance modules configured to implement different...

OBJECTIVES To compare the ability of ophthalmologists versus optometrists to correctly classify retinal lesions due to neovascular age-related macular degeneration (nAMD). DESIGN Randomised balanced incomplete block trial. Optometrists in the community and ophthalmologists in the Hospital Eye Service classified lesions from vignettes comprising clinical information, colour fundus photographs ...

Purpose To identify the spatial distribution of exudative features of choroidal neovascularization in neovascular age-related macular degeneration (nAMD) based on the localization of intraretinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment-epithelial detachment (PED). Methods This retrospective cross-sectional study included spectral-domain optical coherence tomography volume sca...

Parallel languages are tools for constructing eecient application programs, while reducing the required labor. In this light, using the most appropriate tool for each component of a complex system seems natural, resulting in multi-paradigm multilingual programming. The Converse system developed at Illinois addresses the issues involved in supporting multilingual applications. This paper describ...

We present the first unconstrained nonadiabatic molecular dynamics (NAMD) simulations of photocatalytic water oxidation by small hydrated TiO2 nanoparticles using Tully surface hopping and time-dependent density functional theory. The results indicate that ultrafast electron–proton transfer from physisorbed water to the photohole initiates the photo-oxidation on the S1 potential energy surface....

PurposeTo develop consensus terminology in the setting of polypoidal choroidal vasculopathy (PCV) and to validate a set diagnostic criteria not requiring indocyanine green angiography (ICGA) for differentiating PCV from typical neovascular age-related macular degeneration (nAMD) based on combination OCT color fundus photography findings.DesignEvaluation test results.ParticipantsPanel retina spe...

PurposeTo report the 2-year efficacy and safety of abicipar every 8 weeks quarterly (after initial doses) compared with monthly ranibizumab in patients treatment-naïve neovascular age-related macular degeneration (nAMD).DesignTwo multicenter, randomized, phase 3 clinical trials identical protocols (CEDAR SEQUOIA). Analyses used pooled trial data.ParticipantsThe enrolled 1888 (1 eye/patient) act...

PURPOSE To describe the visual acuity and safety outcomes for the first 50 patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab at Moorfields Eye Hospital. METHODS A retrospective analysis of case notes from the first 50 consecutive patients with Primary Care Trust funding for ranibizumab therapy for nAMD. Visual acuity outcomes and adverse events were no...