The antioxidant N-acetylcysteine (NAC) prevented sepsis-induced diaphragmatic dysfunction. As an indirect antioxidant NAC was shown to induce superoxide dismutase (SOD) activity in immune cells from endotoxaemic mice. The aim of this study was to assess whether NAC acts as an indirect antioxidant by inducing manganese (Mn)-SOD activity in the diaphragms of endotoxaemic rats, while preventing mu...

BACKGROUND N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. METHODS Following intraperitoneal (i.p.) administration of ...

Introduction: Arsenic is a highly toxic element that is widely distributed in environment. Antioxidants depletion and oxidative stress is now considered as one of the possible mechanisms of arsenic-induced toxicity. N-acetylcysteine (NAC) and Curcumin (Cur) are potential antioxidants that can compensate the depletion of antioxidants. This study aimed to compare the hepatoprotective effect of Cu...

OBJECTIVES This study was designed to test a rapid protocol of intravenous acetylcysteine for prevention of radiocontrast-induced nephropathy (RCIN). BACKGROUND Oral acetylcysteine (NAC) may provide better prophylaxis against RCIN than intravenous (i.v.) hydration alone. Current protocols preclude prophylaxis of same-day or emergency patients owing to the need for prolonged pretreatment. ME...

Introduction: During coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB), the role of cardioplegic solution which results in cardiac arrest, is critical. This study was planned to evaluate the clinical impacts of N acetylcysteine (NAC) enriched cold-blood cardioplegia on early reperfusion injury in patients with ischaemic heart disease undergoing CABG Methods: In a...

The aim of this study to establish the effect systemic N-acetylcysteine (NAC) administration on oxidative–antioxidative balance, inflammatory markers, and collagen production during wound healing in diabetes. A total 24 male Wistar albino rats were randomly divided into 4 groups: control, streptozotocin-induced diabetic model, NAC treatment group, model with treatment. dorsal circular was creat...

INTRODUCTION Lactate dehydrogenase (LDH), C-Reactive Protein (CRP), D-dimer and feritin are acute phase proteins which levels may rise in the presence of an inflammatory process COVID-19. N-Acetylcysteine (NAC) is antioxidant has also been widely considered as adjunctive therapy We aim to analyze effect NAC administration improving oxidative stress inflammation COVID-19 through assessment LDH, ...