Pulmonary-renal syndrome refers to patients with DAH (or pathologic pulmonary purpura on physical examination implies a small-vessel, cutaneous vasculitis ( 10).. The ANCA-associated vasculitides, WG, CSS, and MPA, are grouped. . The syndrome is characterized by a triad of (1) asthma, (2) hypereosinophilia, and . Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatos...

Although unregulated activation of the Ras/Raf/mitogen-activated protein kinase kinase/Erk signaling pathway is believed to be a central mechanism by which many cell types undergo oncogenic transformation, recent studies indicate that activation of Raf kinase by oncogenic Ras is not sufficient to cause tumorigenic transformation in intestinal epithelial cells. Thus, identification of signaling ...

Abstract Background and Aims Estimating prevalence incidence of chronic kidney disease (CKD) based on claims data often underlies bias limitations due to uncertainty diagnostic validity. We investigated CKD over time using from a community-dwelling cohort individuals aged 70+ linked individual data. assessed the validity claims-based compared with eGFR-based definition. Method in two sources: 1...

Sclerotinia stem rot is one of the most devastating diseases of rapeseed in China, which causes yield loss ranging from 10 to 80%. The objective of this study was to detect the QTLs associated with this disease. A partial sclerotinia resistance rapeseed line M083 was crossed with a sensitive one APL01, and the BC1F1 derived from this cross was used as a mapping population. The 182 lines of BC1F...

During human pregnancy, the production of 17-beta-estradiol (E2) rises steadily to eighty fold at term, and placenta has been found to specifically bind estrogens. We have recently demonstrated the expression of estrogen receptor alpha (ER-alpha) protein in human placenta and its localization in villous cytotrophoblast (CT), vascular pericytes, and amniotic fibroblasts. In vitro, E2 stimulated ...

BACKGROUND Despite the use of low-osmolar contrast media that have significantly reduced the occurrence of severe adverse reactions, contrast-induced (CI) acute kidney injury (AKI) remains the third cause of AKI in hospitals. We sought to estimate the frequency of CI-AKI among hospitalized patients undergoing image-guided cardiovascular procedures, to quantify the effect of risk factors on the ...