نتایج جستجو برای: n terminal pegylation
تعداد نتایج: 1072666 فیلتر نتایج به سال:
Currently, there are more than 35 US FDA-approved NPs utilizing PEG in their biomedical applications. PEGylation, which is the addition of PEG to the NP formulation, provides immunity from the hostile biological environment. The ‘stealth’ property, further confers on the PEG-NP formulation benefits that are not normally provided by other polymers. This mini-review briefly describes the mechanis...
This study evaluates the influence of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice. Polymer- or peptide-coated 64Cu-labeled QDs 2 or 12 nm in diameter, with or without polyethylene glycol (PEG) of molecular weight 2000, are studied by serial micropositron emission tomography imaging and region-of-interest...
Enzymatic approaches of protein PEGylation are widening their applications thanks to the advantageous obtainment of homogeneous mono-PEGylated isomers. Microbial transglutaminase (mTGase) is an enzyme that, in nature, forms protein cross-linkings between side chains of Gln and Lys residues. For protein PEGylation, mTGase allows site-specific modification with PEG-NH2 at precise glutamines of th...
Proteins that are modified by chemical conjugation require at least two separate purification processes. First the bulk protein is purified, and then after chemical conjugation, a second purification process is required to obtain the modified protein. In an effort to develop new enabling technologies to integrate bioprocessing and protein modification, we describe the use of disulfide-bridging ...
The bacterial plasminogen-activator staphylokinase (Sak) is a promising thrombolytic agent for treating acute myocardial infarction. To effectively reduce the immunogenicity of Sak while maintaining its fibrinolytic activity, site-specific PEGylation was performed in the present study. The chemoselective cysteine PEGylation site was selected within an immunodominant region (amino acid residues ...
To prepare long-circulating liposomes, poly(ethylene glycol) (PEG)-lipid is usually mixed with other lipid components before vesicle formation. PEG-lipids can also be postinserted in the outer layer of liposomes after the preparation. In this study, PEG-distearoylphosphatidylethanolamine was incorporated by postinsertion technique into liposome-encapsulated hemoglobin (LEH) carrying neutral or ...
PEGylation of antibodies is known to increase their half-life in systemic circulation, but nothing is known regarding whether PEGylation can improve the inhibitory potency of antibodies against target receptors. In this paper, we have examined this question using antibodies directed to Sialoadhesin (Sn), a macrophage-restricted adhesion molecule that mediates sialic acid dependent binding to di...
Purpose: Determination of changes of glycoconjugates, which have special terminal sugars, in embryonic developmental processes of brain stem and trigeminal nucleus in Balb/C mouse. Materials and Methods: In this study mice embryos between 10-17 embryonic days were used. They were fixed according to ordinary laboratory procedures. The specimens were embedded in paraffin and serial sections with...
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