soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. however, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 mapk) as the main therapeutic targets were...

in order to investigate of different salinity stress and plant densities effects on quantitative and qualitative forage and grain yields of kochia a randomized complete block design in factorial arrangement with three replications was used. a field study was conducted in 2011 cropping season in agriculture experiment satiation, college of agriculture, islamic azad university, arak branch treatm...

background : 5-fluorouracil could lead to a decline in fertility in caenorhabditis elegans. the aim of this study was to describe the mechanisms underlying such an altered fertility phenotype and to illustrate the specific genes and path-ways that are involved in the related phenotypic changes in c. elegans. methods : we isolated total rna from the samples and used a new method called digital g...

background and objectives: over the last two decades, a large number of researches have been conducted regarding the importance of nitrogen in sugar beet. this indicate that there were needs to investigate more on nitrogen management to achive higher production and quality because less nitrogen application result in reducing yield and high nitrogen application would increase production costs an...

background interleukin (il)-2 plays a central role in t cell-dependent immune responses. objectives we conducted this study to determine and compare il-2 expression in lupoid and usual types of old world cutaneous leishmaniasis (owcl), using immunohistochemistry. patients and methods thirteen paraffin-embedded specimens of lupoid and 12 specimens of usual types of owcl were used. a mouse monocl...

abstract:â green spaces, especially urban gardens have been a subject of study in many countries for a long time, but the subject has been mostly overlooked in iran. therefore, this study tries to analyze the changes in land use and how we can protect green spaces (gardens) in jahrom in line with sustainable development in 1996-2006. the data in this study were collected through local investiga...

the effects of waterlogging, sewage sludge and animal manure on the concentrations of dtpa extractable copper, iron, manganese and zinc were investigated in two different types of soil. a factorial experiment based upon a completely randomized design of two replications containing duration of waterlogging at six levels (0, 1, 3, 7, 15, 30 days), source of organic fertilizer at three levels (con...

mechanisms of drought stress tolerance of gf677 rootstock, peach and almond hybrid, (prunus persica × prunus amygdalus) were studied under in vitro conditions. plantlets of gf677 rootstock were subcultured into the murashige and skoog (ms) solid proliferation medium containing 1 mg/l ba (6-benzyladenine) and 0.1 mg/l naa (naphthaline acetic acid) in four drought stress levels 0 (control), 10, 2...

in this research priority of gorgan’s sub- watershed were done after normalizing the indicators using gis software. the multi-attribute decision-making methods including electre, topsis and saw were used in this study. ahp was applied in order to weighting the indicators in expert choice software. first, priority the sub-watershed were done by electre, topsis and saw using the excel. each metho...

objective(s) pde3 has a functional role in insulin secretion and action. we investigated the metabolic effects of new synthetic pde3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. materials and methods the test compound or solvent was injected subcutaneously to mice, for 7 days. on day 8, blood and liver samples were obtained. in hyperglycemic rat, 0.5 g/kg glucose with or w...