soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. however, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 mapk) as the main therapeutic targets were...

introduction due to the development of sustainable agriculture and the reduction of utilizing chemical fertilizers, it is essential to use organic fertilizer. organic matter is vital to soil fertility and its productivity. to maintain the level of fertility and the strength of soil, organic matter levels should be maintained at an appropriate level. unfortunately, the level of organic matter in...

in rainfed areas of iran, cereal yields are low, variable and mainly as a result of inadequate and erratic seasonal rainfall and associated management factor, such as late sowing date (or late crop germination). in order to investigate the effects of single irrigation and nitrogen on bread wheat (triticum aestivum l. var. sabalan) a field experiment was conducted as split plot arranged in a ran...

background: mammography is the primary imaging technique for detection and diagnosis of breast cancer; however, the contrast of a mammogram image is often poor, especially for dense and glandular tissues. in these cases the radiologist may miss some diagnostically important microcalcifications. in order to improve diagnosis of cancer correctly, image enhancement technology is often used to enha...

background: in this study, two-dimensional gel electrophoresis (2-de) method was applied to determine and compare the protein spots expressed in the two field isolates of leishmania major and recovered from the patients who were clinically sensitive and resistant to glucantime® treatment. methods: leishmania parasites were isolated from the cutaneous lesions of two cl infected patients in shira...

religious tourism is one of the varieties of tourism that authorities in this filed , believe iran, due to its special cultural and religious capacities and geographical position , has an important role in developing religious tourism industry. one of the important factors that affects industry tourism, especially developing the religious one ,is the aerial transportation industry for the time ...

due to the use of secale montanum for different rangelands reclamation across the country, management of these ecosystems need to be aware of its ability to environmental stresses. this research investigated the effect of pollutant element of cu and pb on seed germination and growth of this species in laboratory. therefore, the effect of five treatments (control, 50, 100, 150, 200ppm) of pb (no...

glucose-6-phosphate dehydrogenase is an essential enzyme to cell growth. its deficiency of enzyme plays an important role in senescence and death signaling. also, it is actually the most common clinically important enzyme defect, not only in hematology, but also among all human known diseases. clinical consequences of enzyme deficiency are: neonatal hyperbilirubinemia, acute hemolytic anemia, a...

background phytotherapy is a popular treatment option in cases of benign prostatic hyperplasia (bph), with many different herbal products being used for the treatment of this condition. withania coagulans (wc) is an herbal medicine that has shown anti-tumoral, anti-inflammatory, and antioxidant effects. objectives this study examined the effect of withania coagulans extract (wce) on prostatic c...