the c3 phenotypes were determined by high-voltage agarose gel electrophoreses in german patients suffering from lymphosarcoma (n=34), hodgkin (n=59) and a group of other haematological diseases (n=46). frequencies of c3 ss, sf and ff pho=enotypes were not significantly different from the frequencies found in a control group of 322 healthy germans. however, high frequency of the ff phenotype in ...

background and purpose: skin cancer is one of the most common types of cancer. several studies suggest a high incidence of skin cancer in most countries. timp-2 is the tissue inhibitor of matrix metalloproteinase and exist in both cancer and normal cells. the aim of this study was to investigate the expression of timp-2 gene in patients with skin cancer and evaluating the association between th...

myostatin (mstn), also known as growth and differentiation factor-8 (gdf8), is a member of the transforming growth factor beta (tgf-?) superfamily that decreases growth in mammals. a single nucleotide polymorphism (snp) in the myostatin (gdf8) 3'utr of oar2 has been known as responsible for muscular hypertrophy in foreign breeds. in this study, in order to identify single nucleotide polymo...

Background: The purpose of present study was to investigate whether Sphingosine 1-phosphate (S1P) levels and its receptors gene expressions are correlated with MyoD and myogenin following resistance training. Materials and Methods: 24 eight-week-old male Wistar rats (190-250 gr) were assigned randomly to a control (N = 12) or training (N = 12) group. Rats climbed a resistance training ladder...

Background: The aim of this study was to understand any association between differentiated thyroid carcinoma (DTC) and Ile3434Thr XRCC7 gene polymorphism (GenBank accession number: rs7830743). DTC is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. XRCC7 gene encodes a protein that functions in non-homologous end joining DNA repair pathway. Non-synony...

several studies point to an important function of cyclooxygenase (cox) and prostaglandin signaling in models of synaptic plasticity which is associated with n-methyl-d-aspartate receptors (nmdars). cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by nmda dependent synaptic activity. nonsteroid antiinflammatory drugs (nsaids) exert their antiinf...

objective(s):  coronary artery disease (cad) which may lead to myocardial infarction (mi) is a complex one. great effort has been devoted to identification of genes that increase susceptibility to cad or provide protection. a 21-bp deletion in the mef2a gene, which encodes a member of the myocyte enhancer factor 2 family of transcription factors, has been reported in patients of a single pedigr...

background: the purpose of present study was to investigate whether sphingosine 1-phosphate (s1p) levels and its receptors gene expressions are correlated with myod and myogenin following resistance training. materials and methods: 24 eight-week-old male wistar rats (190-250 gr) were assigned randomly to a control (n = 12) or training (n = 12) group. rats climbed a resistance training ladder wi...

Background: Vitrification of oocytes is a fast-freezing technique, which may affect the quality of the human oocyte, and consequently affects the embryo development, pregnancy and birth. The aim of the current study was to investigate the consequence of in-vitro vitrification on maturation status of immature human oocytes, additionally, expression levels of stress, and apoptosis related genes. ...