Except in the most hindered of cases, N,N'-diaryl N,N'-dimethyl ureas adopt a conformation with the two aryl rings disposed cis to one another. Variable temperature NMR studies reveal the rate at which the Ar-N bonds rotate as well as the conformational preference of ortho disubstituted ureas in which more than one cis orientation is possible. In general, a conformation in which the aryl rings ...

2,10-Disubstituted phenothiazines are the best drugs in psychiatry. Several methods for their analysis have been reported in the literature. The official methods are based on non-aqueous titration or spectrophotometry. Various oxidizing agents have been used for the spectrophotometric determination of 2,10-disubstituted phenothiazines, e.g. Ce(SO4)2, NH4VO3, K2S208, KIO4, KIO3, KBrO3, FeCl3, Na...

A novel Pd-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates has been realized under mild reaction conditions. This method provides an efficient access to N-mono- or N,N-disubstituted benzamides and benzoates.

Urea forms a 1:1 solvate with N,N-dimethyl-acetamide (DMA) [systematic name: diamino-methanal-N,N-dimethyl-acetamide (1/1), C(4)H(9)NO·CH(4)N(2)O] with both mol-ecules positioned on a twofold axis, giving rise to rotational disorder of the DMA mol-ecule. The mol-ecules display a layered structure in which urea mol-ecules form hydrogen-bonded ribbons bounded by mol-ecules of solvent.

Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...

In the title compound, C(17)H(20)N(2)O(4), the 2,5-dimeth-oxy-phenyl unit is almost planar, with an r.m.s. deviation of 0.015 Å. The dihedral angle between the 2,5-dimeth-oxy-phenyl ring and the urea plane is 20.95 (8)°. The H atoms of the urea NH groups are positioned syn to each other. The mol-ecular structure is stabilized by a short intra-molecular N-H⋯O hydrogen bond. In the crystal, inter...

In the title compound, C(15)H(14)F(2)N(2)O(3), the dihedral angle between the benzene rings is 64.5 (1)°. One F atom is disordered over two meta positions, with occupancy factors of 0.72 and 0.28. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds involving two N-H and one C=O groups of the urea central fragment, leading to a supra-molecular chain along [011].