Introduction Conclusions References

Most neurodegenerative diseases, such as Alzheimer’s disease (AD), have been identified as multifactorial diseases characterized by a progressive decline in physiological functions. Impairment of the mitochondrial respiratory chain has been extensively described in relation to AD. It has been reported that the amyloid species Aβ1-42 may be implicated in mitochondrial dysfunction, leading to cel...

OBJECTIVE To evaluate the efficacy of transmyocardial revascularization performed on patients with refractory class IV or unstable angina with a holmium:yttrium-aluminum-garnet laser. METHODS Transmyocardial revascularization with a holmium:yttrium-aluminum-garnet laser was performed in 42 patients with refractory angina who were not candidates for percutaneous transluminal coronary angioplas...

We have reported previously that N-acetyl-L-cysteine facilitated interleukin-1b–induced nitric oxide synthase (iNOS) expression in rat vascular smooth muscle cells. The present study compares the effect of N-acetyl-L-cysteine with other antioxidants and tested the possibility that N-acetyl-L-cysteine potentiates iNOS induction by a mechanism involving activation of p44/42 mitogen-activated prot...

We have reported previously that N-acetyl-L-cysteine facilitated interleukin-1beta-induced nitric oxide synthase (iNOS) expression in rat vascular smooth muscle cells. The present study compares the effect of N-acetyl-L-cysteine with other antioxidants and tested the possibility that N-acetyl-L-cysteine potentiates iNOS induction by a mechanism involving activation of p44/42 mitogen-activated p...

Background Cerebrospinal fluid (CSF) biomarkers have shown incomplete concordance with amyloid-positron emission tomography (PET). Our goal was to analyze the agreement between CSF and amyloid-PET in a multicenter study. Method Retrospective study (6 centers). Participants who underwent both maximum time tests <18 months were included. Biomarkers considered abnormal according cut points of each...