The asymmetric unit of the title compound, C16H22N2O2S, contains two crystallographically independent mol-ecules (A and B). In mol-ecule A, the cyclo-hexane ring is disordered over two orientations [occupancy ratio 0.841 (10):0.159 (10)]. In each mol-ecule, the central carbonyl thio-urea unit is nearly planar (r.m.s. deviations for all non-H atoms of 0.034 Å in mol-ecule A and 0.094 Å in mol-ec...

BACKGROUND The efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria may be threatened by parasites with reduced responsiveness to artemisinins. Among 298 ACT-treated children from Mbita, Kenya, submicroscopic persistence of P. falciparum on day 3 posttreatment was associated with subsequent microscopically detected parasitemia at days 28 or 42. METHODS DNA...

The C( He,d) N proton transfer reaction has been measured at an incident energy of 26.3 MeV. Angular distributions for proton transfer to the ground state and excited states at 2.313 and 3.948 MeV in N are analyzed within the framework of the modified DWBA. Asymptotic normalization coefficients ~ANC’s! defining the amplitude of the tails of the N bound-state wave functions in the C1p channel ar...

There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF). The pathogenesis of this entity remains unclear; however, our recent observations suggest a likely mechanism for the initial dermal manife...

We have characterized N-13 ammonia as a myocardial blood flow imaging agent suitable for positron-emission computed tomography. However, the mechanisms of uptake and retention of this agent in myocardium are not known, and effects of altered metabolism were not considered. Therefore, we studied the uptake and retention of N-13 ammonia in myocardium under various hemodynamic and metabolic condit...

The title compound, C8H10N2S, was prepared by reaction of methyl-amine solution, KOH and phenyl-iso-thio-cyanate in ethanol. It adopts a syn-Me and anti-Ph conformation relative to the C=S double bond. The dihedral angle between the N-C(=S)-N thio-urea and phenyl planes is 67.83 (6)°. In the crystal, the mol-ecules centrosymmetrical dimers by pairs of N(Ph)-H⋯S hydrogen bonds. The dimers are li...

Sir: During the course of our screening for inducers of mouse myeloid leukemic cell (M1)1) differentiation, we have recently isolated four active components related to the carminomycins from the cultured broth of an actinomycete. The isolation and structures of these components are reported in this paper. The producing organism of the active substances was isolated from a soil sample collected ...

History has had its periods of magnificent excess, when vast amounts of human effort were devoted to cultural projects that transcended the necessities of survival and commerce. Obvious examples begin with the construction of the great pyramids. Much later, Europe's cathedrals were the ultimate commitment of society's surplus energy to expressions of the spirit. The explorations of the remote r...