buckwheat rutin has been found to be able to inhibit angiotensin ii (angii) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. in this study, myocardial hypertrophy model was made by adding angii to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. intrac...

AIMS Anderson-Fabry Disease (AFD), an X-linked disorder of sphingolipid metabolism, is a cause of idiopathic left ventricular hypertrophy but the mechanism of hypertrophy is poorly understood. Gadolinium enhanced cardiovascular magnetic resonance can detect focal myocardial fibrosis. We hypothesised that hyperenhancement would be present in AFD. METHODS AND RESULTS Eighteen males (mean 43+/-1...

Buckwheat rutin has been found to be able to inhibit angiotensin II (AngII) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. In this study, myocardial hypertrophy model was made by adding AngII to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. Intrac...

BACKGROUND/AIMS Numerous epidemiological studies have associated elevated serum phosphorus levels with cardiovascular disease and the risk of death in the general population as well as in chronic kidney disease (CKD) and dialysis patients. In this study, we explored whether elevated phosphate conditions induce cardiac hypertrophy and attempted to identify the molecular and cellular mechanisms i...

OBJECTIVE Myocardial hypertrophy often develops in response to hypertension, and it is causal to and an independent predictor of heart failure. Several risk factors modify the progression of hypertrophy, the associated progressive impairment of myocardial function, and eventually the transition to overt congestive heart failure. The aim of the present study was to investigate the effects of smo...

AIMS To evaluate the prevalence and the independent prognosis of electrocardiographic left ventricular hypertrophy by voltage only, ST depression and negative T wave, isolated negative T wave and left ventricular hypertrophy plus ST depression and negative T wave for cardiac morbidity and mortality, without known ischaemic heart disease at baseline. METHODS AND RESULTS Follow-up data from the...

BACKGROUND Uncoupling protein 2 (UCP2) is critical in regulating energy metabolism. Due to the significant change in energy metabolism of myocardium upon pressure overload, we hypothesize that UCP2 could contribute to the etiology of cardiac hypertrophy. METHODS Adult male C57BL/6J mice were subjected to pressure overload by using transverse aortic constriction (TAC), and then received genipi...

THE TERM primary myocardial disease refers to a variety of cardiac enlargement which is of unknown cause and frequently leads to cardiac dilatation, congestive heart failure, and finally to death. There are a number of synonyms. The disorder is also called idiopathic myocardial hypertrophy,' myocardiopathy, cardiac hypertrophy of unknown cause, and, especially in Great Britain, cardiomyopathy. ...

Background By exploiting the paramagnetic properties of deoxyhemoglobin, blood oxygen level-dependent (BOLD) MRI can detect myocardial ischemia in patients with coronary artery disease. However, little is known about myocardial tissue oxygenation in pathological left ventricular hypertrophy (e.g. HCM) or physiological hypertrophy (e. g. elite athletes). Perfusion studies have shown that patient...