نتایج جستجو برای: myeloperoxidase deficiency
تعداد نتایج: 143382 فیلتر نتایج به سال:
Hereditary deficiency of myeloperoxidase (MPO) is a common disorder but its genetic basis is unknown. We have reported that neutrophils from individuals with MPO deficiency lack enzymatic and immunochemical evidence for mature MPO but have a 90-kDa precursor protein. We have thus hypothesized that hereditary MPO deficiency reflects a defect in processing of a mutated primary translation product...
Glutathione is an important antioxidant in the lungs but its concentration is low in the airways of patients with cystic fibrosis. Whether this deficit occurs from an early age or how oxidative stress contributes to lowering glutathione is unknown. We measured glutathione, its oxidation products, myeloperoxidase, and biomarkers of hypochlorous acid in bronchoalveolar lavage from children with c...
The objective : to assess changes in the level of lactoferrin and ferritin patients with pulmonary tuberculosis COVID-19 during treatment, determine their correlation parameters free radical oxidation antioxidant protection. Subjects methods . Levels erythrocyte catalase ferritin, neutrophil myeloperoxidase were studied against background successful treatment group (n = 80) 75). Their protectio...
dendritic cells function as the main cellular population responsible for professional antigen presentation and hence for induction of primary immune responses. although they are present in virtually every tissue, nevertheless their number is usually so low that it makes their isolation for studies very difficult. in this study, we purified dendritic cells from mouse spleen by a three-step enric...
background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...
Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo. Six hours after an intraplantar injection of zymosan, Cot/tpl2(-/-) mice showed a 47% reduction in myeloperoxidase activity, concomitant with a 46% lower neutrophil recruitment and...
Myeloperoxidase (MPO) is a critical component in the oxygen-dependent microbicidal activity of neutrophils. Hereditary deficiency of MPO occurs commonly, but its genetic basis has not been determined. Previously we have reported the presence of an 89-kilodalton protein, likely pro-MPO, in normal and MPO-deficient neutrophils and hypothesized that the absence of peroxidase activity in neutrophil...
The nitroxide tempol (4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl) reduces tissue injury in animal models of inflammation by mechanisms that are not completely understood. MPO (myeloperoxidase), which plays a fundamental role in oxidant production by neutrophils, is an important target for anti-inflammatory action. By amplifying the oxidative potential of H2O2, MPO produces hypochlorous aci...
Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated with ANCA. The most common ANCA target antigens are myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the alternative complement pathway, passive transfer of antibodies to mouse MPO (anti-MPO) induces a mouse model of ANCA NCGN that closely mimics human disease. ...
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