Mycosis fungoides is a rare type of non-Hodgkin's lymphoma of T cells that primarily affects the skin. It is characterized by the presence of erythematous plaques that evolve into ulcerated lesions, tumors throughout the skin or even bone marrow infiltration in advanced stages. Chemotherapy and topical steroids, phototherapy and radiotherapy are treatment options for early cases. This study rep...

CTCL: cutaneous T-cell lymphoma FOLFOX: folinic acid, fluorouracil, oxaliplatin MF: mycosis fungoides INTRODUCTION Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL). The neoplastic T cells in MF are usually mature CD4 T cells, and CD8 phenotype expression is rarely observed. There are 2 categories of CD8 CTCL, one with aggressive behavior and one with indolent b...

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Folliculotropic mycosis fungoides (FMF) is a variant of (MF) noted in the World Health Organization — European Research and Treatment Cancer (WHO/EORTC) update 2018. FMF characterized as subtype with worse prognosis than classic MF. The situation changed recently when authorities proposed dividing into two prognostically different subtypes: indolent aggressive. Indolent allows 92% patients to s...

Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10-60 mg. All 4 patients were erythrodermic, which may have predisposed them to this toxic effect. It is ...