The time trade-off (TTO) valuation technique is widely used to determine utility values of health outcomes to inform quality-adjusted life-year (QALY) calculations for use in economic evaluation. Protocols for implementing TTO vary in aspects such as the trade-off framework, iteration procedure and its administration model and method, training of respondents and interviewers, and quality contro...

We consider the hedging problem in an arbitrage-free financial market, where there are two kinds of investors with different levels of information about the future price evolution, described by two filtrations F and G = F ∨ σ(G) where G is a given r.v. representing the additional information. We focus on two types of quadratic approaches to hedge a given square-integrable contingent claim: loca...

The hydrogenase content of the genome of Geobacter sulfurreducens, a member of the family Geobacteraceae within the delta-subdivision of the Proteobacteria, was examined and found to be distinct from that of Desulfovibrio species, another family of delta-Proteobacteria on which extensive research concerning hydrogen metabolism has been conducted. Four [NiFe]-hydrogenases are encoded in the G. s...

The biochemical basis for sulfite accumulation by sulfate-using revertants of Salmonella pullorum was determined. All of the sulfate-using mutants isolated from wild-type S. pullorum accumulated sulfite when grown at 37 but not at 25 C. The specific activity of reduced nicotinamide adenine dinucleotide (NADPH)-dependent sulfite reductase (H2S-NADP oxidoreductase, EC 1.8.1.2) and of reduced meth...

Previous studies suggested that the aryl hydrocarbon receptor (AhR) contributes to mice reproduction and fertility. However, the mechanisms involved remain mostly unknown. Retrotransposon silencing by Piwi-interacting RNAs (piRNAs) is essential for germ cell maturation and, remarkably, AhR has been identified as a regulator of murine B1-SINE retrotransposons. Here, using littermate AhR+/+ and A...

background :cell proliferation is one of the most critical factors in metastasis and prognosis of the malignant tumors.recent investigations show that the eosinophil granolosytes have an important role in developing of malignant tumors. the relation between cell proliferation and eosinophilic infiltration in oral squamous cell carcinoma (oscs) with prognosis is unclear.the aim of this study was...

DNA methylation is necessary for the silencing of endogenous retrotransposons and the maintenance of monoallelic gene expression at imprinted loci and on the X chromosome. Dynamic changes in DNA methylation occur during the initial stages of primordial germ cell development; however, all consequences of this epigenetic reprogramming are not understood. DNA demethylation in postmigratory primord...

possibility of postnatal oogenesis in humans and other species has become one of today's most debated topics in the fields of reproductive and developmental biology. Wilhelm Waldeyer concluded in 1870 that oocyte production ceases with birth, and for more than a century scientists have been in consensus that the number of oocytes is gradually reduced throughout adult life [1]. A contemporary un...

Objective: To study whether the generated CD1a positive cells belong to the leukemic cells among patients with juvenile myelomonocytic leukemia. Materials and Methods: We used mononuclear cells from 3 patients with juvenile myelomonocytic leukemia, from which two had monosomy 7. The mononuclear cells from these patients were cultured in RPMI/10%FCS without adding exogeneous growth factors fo...