Despite the extensive use of Mumps virus vaccines for almost forty years, there is still a paucity of knowledge concerning the Host-Pathogen Interaction. This paper reviews the advances in our knowledge of the antiviral immune response with particular reference to the selection of attenuated mumps virus strains used in different vaccine formulations. The ability of mumps viruses to evade the in...

In 2012, mumps was introduced from Bosnia and Herzegovina to Vojvodina, causing an outbreak with 335 reported cases. The present manuscript analyses the epidemiological and laboratory characteristics of this outbreak, identifies its main causes and suggests potential future preventive measures. Sera of 133 patients were tested for mumps-specific antibodies by ELISA and 15 nose/throat swabs were...

The effects of a mumps virus infection on functional properties of embryonic hippocampal neurons in culture were analysed with special emphasis on voltage-dependent Ca2+ channels. Cultures with higher or lower density of glial cells (not treated or treated with mitotic inhibitor, respectively) were infected with the relatively non-cytolytic RW strain of mumps virus and currents were recorded fr...

5.5-fold increase in antimumps IgG antibody concentration to 16,000 IU/mL. The third case occurred in a 30-yearold male pediatric resident with no history of mumps vaccination who had mumps disease during childhood. He had an antimumps IgG antibody concentration of 33 IU/mL in a serum sample obtained for screening for newly employed health care workers at our institution. One year later, the pa...

Most mumps patients are clinically diagnosed without any virological examinations, but some diagnosed cases of mumps may be caused by other pathogens or secondary vaccine failure (SVF). To clarify these issues, a sensitive, specific, and rapid diagnostic method is required. We obtained 60 salivary swabs from 34 patients with natural infection during the course of the illness, 10 samples from pa...

Until the 1970s, mumps was one of the most common pediatric infectious diseases. Childhood mumps, which most often manifested as fever and bilateral par-otitis, was generally not very severe but could result in meningoencephalitis, and in adult men, it could lead to painful or-chitis. Fortunately, this latter complication was generally unilateral and rarely led to decreased fertility [1]. With ...

Abstract Background Updated seroprevalence studies of infections in migrants may aid the design tailored vaccination and prevention programmes. The objective this study was to describe rates for potentially transmissible viral attended at a referral centre major European city. Methods Descriptive analysis vaccine-preventable non-vaccine-preventable Madrid, Spain (2018–19). Recorded variables in...

This study sought to investigate persistent measles virus infection of the intestine: a novel protocol for immunogold electron microscopy was developed using a polyclonal anti-measles nucleoprotein antibody on reprocessed, formalin fixed paraffin wax embedded tissue sections. Antibody binding was detected using both immunoperoxidase and light microscopy on tissue sections, and 10 nm gold conjug...

discussion pcr or enzyme linked immunosorbent assay (elisa) on serum or cerebrospinal fluid would be the inevitable basis for accurate diagnosis in such cases. case presentation we reviewed three patients diagnosed with aseptic meningitis due to acute non-mumps associated parotitis based on clinical and laboratory findings. while there are many similarities between the clinical characteristics ...

Experiments were conducted in which rhesus monkeys were infected with mumps virus by inoculation into the parotid gland. Virus was isolated from buccal swab specimens from animals up to 6 days after inoculation. Immunofluorescence staining for mumps antigen was positive, and infectious virus was recovered from tissue biopsies of inoculated glands. Histological examination of biopsied glands rev...