background: tuberculosis (tb) is a major worldwide public health problem. the incidence of tuberculosis has decreased in iran in recent years. however, despite this dramatic decline, tuberculosis is still considered to be a major health problem in iran. objectives: the aim of this study was to investigate the epidemiological situation and main characteristics of tuberculosis in iran. patients a...

The emergence of multidrug-resistant Gram-negative bacteria, in particular Acinetobacter baumannii and Pseudomonas aeruginosa, is a critical clinical problem worldwide. Antimicrobial peptides (AMPs) have received increasing attention due to their ability to overcome multidrug-resistant microbes. We recently reported that cysteine-functionalized alpha-helical peptides LLKKLLKKC and CLLKKLLKKC ef...

To the Editor: In many parts of the world, the proportions of methicil-lin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant en-terococci, and extended-spectrum β-lactamase (ESBL)–producing organisms in the family Enterobacteriaceae have increased remarkably during recent years (1). However, proportions of antimicrobial drug resistance vary substantially at national and regional leve...

Despite big advances in antimicrobial therapies and infection strategies, the emergence of antibiotic resistance represents an emergency situation, especially in immunocompromised hosts. Specifically, infections due to multidrug resistant, gram-negative pathogens are responsible for high mortality rates and may leave few effective antimicrobial options. Furthermore, although new compounds are a...

Campylobacter spp. and Salmonella are the two most frequent zoonotic bacteria involved in human enteric infections European Union. Both enteropathogens have been isolated from a diversity of wild birds Northern Europe, but there is limited information about gulls as potential reservoirs Southern Europe. A broad sampling fledglings nine colonies yellow-legged gull (Larus michahellis, N = 1222) A...

Results: Multidrug-resistant bacteria were isolated in 75 cases (82.4%) and drug-sensitive bacteria in 16 (17.6%). Clinical and epidemiological characteristics were not statistically different between the groups. Staphylococcus aureus was responsible for 27.5% of ventilator-associated pneumonia episodes and Pseudomonas aeruginosa for 17.6%. Early-onset ventilator-associated pneumonia occurred i...

Introduction: Greatly increased use of antifungal therapies has resulted in the development of multidrug resistant. The phenolic compound carvacrol have been reported to have anti-Candida activity. This work is an attempt to examine effect of carvacrol on ergosterol synthesis against multidrug resistant Candida albicans. Methods: This cross-sectional study has been conducted on 30 immune-compr...

BACKGROUND Multidrug-resistant Pseudomonas aeruginosa has emerged as one of the most important healthcare-associated pathogens. Colistin is regarded as the last-resort antibiotic for multidrug-resistant Gram-negative bacteria, but is associated with high rates of acute kidney injury. The aim of this in vitro study is to search for an alternative treatment to colistin for multidrug-resistant P. ...