We characterized a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of antimicrobial resistance genes. An (Ec61) was recovered in 2014 from transtracheal aspirate sample patient admitted to Brazilian tertiary hospital and submitted further microbiological genomic characterization.

Emergence of resistance to two most potent first line anti-TB drugs i.e. isoniazid and rifampicin (multidrug resistant TB MDR TB) is well known, but, the second line drugs used to treat MDR-TB are also showing resistance to the same strain of Mycobacteria (extensively drug resistance TB, XDR-TB). We report 3 children with partial XDR TB. Two responded to treatment while one was lost to follo...

The extensive progress of genome sequencing projects in recent years has demonstrated that multidrug resistance (MDR) transporters are widely spread among all domains of life. This indicates that they play crucial roles in the survival of organisms. Moreover, antibiotic and chemotherapeutic treatments have revealed that microorganisms and cancer cells may use MDR transporters to fight the cytot...

multidrug resistant (mdr) bacteria are spread through the world which causes nosocomial infections, especially in intensive care unit (icu). this study aimed to investigate resistance pattern of pseudomonas aeruginosa and enterobacter cloacae isolated from patients in icu. during 2011-2012, 30 isolates for each p. aeruginosa and e. cloacae were collected from patients who acquired nosocomial in...

The present study reports the reversing effects of extracts from P. americana on multidrug resistance of BEL-7402/5-FU cells, as well as a preliminary investigation on their mechanism of action. A methylthiazolyl tetrazolium (MTT) method was applied to determine the multidrug resistance of BEL-7402/5-FU, while an intracellular drug accumulation assay was used to evaluate the effects of a column...

Resistance to chemotherapeutic agents is a major obstacle in cancer treatment. A recently proposed strategy target the collateral sensitivity of multidrug resistant (MDR) cancer. Paradoxically, toxicity certain metal chelating increased, rather than decreased, by function P-glycoprotein (Pgp), which known confer resistance effluxing compounds from cells. We have characterized and compared solut...

Multidrug-resistant clones of a drug-sensitive human malignant melanoma cell line were isolated by single-step selection in culture medium containing either vincristine (4.5 ng/ml or 7.5 ng/ml), vinblastine (3 ng/ml), or colchicine (8 ng/ml). This protocol yielded primary colonies showing relatively low (4- to 24-fold) levels of drug resistance. These clones exhibit the classical multidrug resi...

Multidrug-resistant (MDR) tuberculosis (TB) (resistance to at least isoniazid and rifampicin), with >480000 cases in 2013, 10% of them being affected by extensively drug-resistant (XDR)-TB (MDR-TB with additional resistance to any fluoroquinolone, and to injectable second-line drugs (SLDs) (capreomycin, kanamycin or amikacin)), continues to represent a real threat to TB control [1–4]. In some h...

One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1). We investigated a possible...

Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer. Previous studies have indicated that sinomenine can enhance the absorption of various P-gp substrates. In the present study, we investigated the effect of sinomenine on the chemoresistance in colon cancer cells a...