A methodological study devoted to the Mannich-like multicomponent synthesis of the antiplatelet agent (±)‑clopidogrel (7) and the ethyl ester analogue 6 is described. The process involves the formation of 2-chlorophenyl zinc bromide (2) and its subsequent reaction with an alkyl glyoxylate and 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (3). We demonstrate that the organozinc reagent 2 also constitu...

Based on a well-known Lie algebra, the multicomponent Guo hierarchy with self-consistent sources is proposed. With the help of a set of non-semisimple Lie algebra, the nonlinear biintegrable couplings of the multicomponent Guo hierarchy with self-consistent sources are obtained. It enriches the content of the integrable couplings of hierarchies with self-consistent sources. Finally, the Hamilto...

the aim of the present work is to prepare an adsorption package to simulate adsorption / desorption operation for both single and multi-component systems in an isothermal condition by different mechanisms such as; local adsorption theory and mass transfer resistance (rigorous and approximated methods). different mass transfer resistance mechanisms of pore, solid and bidispersed diffusion, toget...

aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. this contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. the method is ba...

Phosphonate derivatives were prepared using multicomponent reactions of dialkyl acetylenedicarboxylate with 4-hydroxycumarine in the presence of trimethyl or triphenyl phosphite in good yields.

The high-order ambiguity function (HAF) was introduced for the estimation of polynomial-phase signals (PPS) embedded in noise. Since the HAF is a nonlinear operator, it suffers from noise-masking effects and from the appearance of undesired cross terms and, possibly, spurious harmonics in the presence of multicomponent (mc) signals. The product HAF (PHAF) was then proposed as a way to improve t...

Hydrogels provide mechanical support and a hydrated environment that offer good cytocompatibility and controlled release of molecules, and myriad hydrogels thus have been studied for biomedical applications. In the past few decades, research in these areas has shifted increasingly to multicomponent hydrogels that better capture the multifunctional nature of native biological environments and th...