Free energy perturbation (FEP) is frequently used to evaluate the free energy change of a biological process, e.g. the drug binding free energy or the ligand solvation free energy. Due to the sampling inefficiency, FEP is often employed together with computationally expensive enhanced sampling methods. Here we show that this sampling inefficiency, which stems from not accounting for the environ...

For the four processes of aero engine health management, which are composed of condition monitoring, diagnostics, prognostics and prescriptive action, a four-layer architecture of aero engine health management divided into data layer, transaction layer, decision layer and users layer, is designed based on multi-agent. Corresponding to the function of each layer, six agent roles are defined, suc...

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This paper presents a new way to model clothing worn by articulated implicit characters. A scalar field is produced using ellipsoids as primitives. Isosurfaces are then used to place garments in one or more layers. As each implicit surface is independent, collision detection is not needed. The cloth is a polygonal mesh whose vertices are in turn moved towards their destination isosurface using ...

In this paper, we derive an asymptotically optimal multi-layer coding scheme for entropy-coded scalar quantizers (SQ) that minimizes the weighted mean-squared error (WMSE). The optimal entropy-coded SQ is non-uniform in the case of WMSE. The conventional multi-layer coder quantizes the base-layer reconstruction error at the enhancement-layer, and is sub-optimal for the WMSE criterion. We consid...

Network Address Translation (NAT) and Realm Specific IP (RSIP) were proposed to extend the lifetime of IPv4 architecture. However; NAT and RSIP do not have the ability to communicate with multi-layer private networks. This paper proposes an enhanced framework of multi-layer RealmSpecific IP (MRSIP) that not only inherences all the benejit of RSIP but also provides both end-to-end transparentacc...

This paper proposes new algorithms for the computeraided design and manufacture (CAD/CAM) of 3D woven multi-layer textile structures. Existing commercial CAD/CAM systems are often restricted to the design and manufacture of 2D weaves. Those CAD/CAM systems that do support the design and manufacture of 3D multi-layer weaves are often limited to manual editing of design paper grids on the compute...