Mucous membrane pemphigoid (MMP) is a rare organ-specific autoimmune subepithelial blistering disease with predominantly mucosal erosions, most frequently affecting the gingiva. Erosions in the oral cavity usually result in markedly decreased quality of life. The major autoantigens are BP180 and laminin332, which are components of basement membrane proteins in the skin and mucosa. Diagnosis is ...

BACKGROUND Mucous Membrane Pemphigoid (MMP) is a rare group of chronic autoimmune disorders characterized by blister producing lesions. It is the variant most likely to occur in the oral cavity and eyes. Few studies shows autoimmune bullous diseases associated with human immunodeficiency virus (HIV). CASE PRESENTATION oral blisters, painful ulcerations and eye symblepharon were observed in a ...

BACKGROUND Mucous membrane pemphigoid (MMP) still represents a potentially life- and sight-threatening disease. In a subset of patients with severe MMP, conventional immunosuppressants are ineffective or contraindicated. OBSERVATIONS Twenty-five patients with severe refractory MMP, including 5 with mucous membrane-dominant epidermolysis bullosa acquisita, received 1 or 2 cycles of rituximab (...

Our patient was diagnosed with cicatricial pemphigoid (CP) in 2001. She demonstrated classic clinical findings and underwent biopsies that supported this diagnosis. She unfortunately experienced severe CP involving both of her eyes, oral mucosa, pharyngeal mucosa, and esophagus. Her left eye was seriously affected early in the course of her disease. She experienced significant scarring of the c...

BACKGROUND A growing body of evidence suggests the involvement of naturally occurring CD4+ CD25+ regulatory (nTreg) T cells in autoimmune diseases. OBJECTIVE To evaluate the expression of some nTreg markers in mucous membrane pemphigoid (MMP) lesions. METHODS Lesional biopsies from six patients with untreated MMP were stained immunohistochemically with anti-CD25, -FoxP3, -CD103, and -CCR5. ...

A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cut...

Purpose Ocular mucous membrane pemphigoid (OcMMP) is a rare autoimmune disorder resulting in progressive conjunctival fibrosis and ocular surface failure leading to sight loss in up to 50%. This study was designed to optimize an ocular surface sampling technique for identification of novel biomarkers associated with disease activity and/or progressive fibrosis. Methods Fifty-seven patients wi...

© 2015 The Authors. doi: 10.2340/00015555-1964 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Mucous membrane pemphigoid (MMP) is an autoimmune subepidermal blistering disease involving primarily the mucosae and occasionally the skin (1–3). We report here a case of a Japanese male patient with idiopathic thrombocytopenic purpura (ITP) who later developed MMP with IgG auto...