objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

introduction: regulators of g-protein signaling protein negatively control g protein -coupled receptor signaling duration by accelerating gα subunit guanosine triphosphate hydrolysis. since regulator of g-protein signaling4 has an important role in modulating morphine effects at the cellular level and the exact mechanism(s) of adrenalectomy-induced morphine sensitization have not been fully cla...

Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in cancer, the prognostic signific...

the siberian sturgeon (acipenser baerii) is an economically important species. sturgeon stockassessment during fingerling production is considered to be one of the most difficult phases ofhatchery rearing. the present study investigated the expression of growth hormone (gh)mrna in unfertilized eggs, fertilized eggs, eyed eggs (2 day before hatching), non-viable eggsand newly-hatched siberian st...

background: protozoa related to trypanosome family including leishmania , synthesize enzymes to escape from drug therapy. one of them is ptr1 that its enzymatic activity is similar to dihydrofolate reductase (dhfr). dihydrofolate reductase - thymidylate synthase has a major role in dna synthesis, if it is inhibited, the result would be the death of parasite. since ptr1 activity is similar to dh...

background: activation of the ubiquitin-proteasome pathway in various malignancies, including colorectal cancer, is established. this pathway mediates the degradation of damaged proteins and regulates growth and stress response. the novel human gene, ube2q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies. we sought to investigate the ...

sodium/proton exchangers (nhx) are key players in plant responses to salinity and have a central role in establishing ion homeostasis. nhxs can be localized in tonoplast or plasma membranes, where they exchange sodium ions for protons, resulting in the removal of ions from the cytosol into vacuole or extracellular spaces. in the present study, the expression pattern of the gene encoding na+/h+ ...

Abstract: iNOS is inducible by a variety of factors related to inflammation and referred to as inducible NOS(iNOS). It is regulated at the level of gene expression; once expressed, it produces NO at a high rate. iNOS gene-expression profiling is an important tool in understanding molecular markers of the responses of cells and tissues to external factors. In this article a semiquantitative reve...