Abstract Background ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine against SARS-CoV-2 that has passed phase III clinical trials and now in use across the globe. Although replication-defective normal cells, 28 kbp of genes delivered to cell nucleus alongside S glycoprotein gene. Methods We used direct RNA sequencing analyse transcript expression from genome human MRC-5 A549 lines are non-pe...

The present study reports the potential application of star-shaped poly(?-caprolactones) with different number arms as new drug delivery matrix. Linear and PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique characterized FTIR, DSC, XRD SEM analysis. High yield, encapsulation efficiency loadings obtained for all microspheres. FTIR analysis reve...

Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have using reversed phase semipreparative HPLC and their structures were established to be 8-hydroxyperrottetin F, C-7-C-8 cleaved product, 6’-sulfate 1D 2D NMR, HR-ESI-MS, IR UV spectroscopy. The antimicrobial cytotoxic propertie...

The synthesis of biologically active 1,4-dihyripyridine derivatives using a Calotropis gigantea leaf powder and ZnO NPs used as catalyst under solvent-free conditions at room temperature via grinding method has been established in single-stage, mild, environmentally friendly green process. procedure is fast effective produces high yields. Three cancer cell lines were to assess the cytotoxic act...

Tropheryma whipplei is a bacterial pathogen responsible for wide range of infections in humans, covering asymptomatic carriage, acute infections, chronic isolated and classic Whipple's disease. Although the bacterium commonly found environment, it very rarely causes Genetic comparison clinical isolates has revealed that main variations were region encoding T. surface glycoproteins called WiSP. ...

Abstract Introduction Essential oils (EOs) are complex structures and possess several pharmacological effects. Nanomedicine offers a solution for their major limitations, including poor solubility, volatility, non–controlled release, preventing clinical use. Methods Here, we developed novel delivery system by nanoformulations that were prepared impregnating savory essential oil (SA) into mesopo...