The distribution of XX and XY cells in XX----XY chimaeric mouse testes was analysed by enzyme marker analysis of separated testicular tissues and by in situ DNA marker analysis of air-dried testicular cells and testis sections. XX cells contributed to the Leydig cells, the peritubular cells and the vascularized connective tissue of the tunica albuginea. The Sertoli cells, on the other hand, app...

objective: the properties of self-renewal and divisionin spermatogonial stem cells (sscs) support spermatogenesis. there are a number of reported methods for in vitro ssc culture systems. the development of a culture system that effectively supports isolation and self-renewal ofgermline stem cells (gscs) is of tremendous benefit for clinical trials, experimental research andas potential treatme...

This study was designed to investigate whether administration of zinc sulphate could improve theresponse of mouse testis to degenerative effects of short term exposure heating. Fifty-four adult male Balb/Cmice were anaesthetized and the scrotums of 36 of them were immersed for 15 min in a waterbath at 43°C.Immediately after the heating, half of the heated animals (n = 18) were injected with sal...

The tissue expression patterns of 10 mouse testis cDNAs were analysed by RT-PCR to search for new mammalian meiotic genes. The homologue of the rat synaptonemal complex protein gene SCP1 is expressed in embryonic ovary, adult brain and testis. One novel gene is stringently testis specific and another is expressed exclusively in testis and embryonic ovary. The latter clone is not expressed in th...

At the Cleveland meeting of the American Association of Anatomists, (1912-1913), Curtis1 reported on wax plate reconstructions of the seminiferous tubules of the white mouse, presenting figures of a model of an entire tubule having an actual length of somewhat over 13 em. The tubule completely reconstructed presents the form of an arch, the two ends of the arch lying in close proximity, each te...

In the mammalian testis, the ubiquitin-proteasome system plays important roles in the process that promotes the formation of mature sperm. We recently identified zygote-specific proteasome assembly chaperone (ZPAC), which is specifically expressed in the mouse gonads and zygote. ZPAC mediates a unique proteasome assembly pathway in the zygote, but the expression profile and function of ZPAC in ...