These are consistent with proposals that Fgf10 expression in the developing sensory tissues is required to induce non-sensory development. To determine the otic epithelial functions of Fgf3 and Fgf10, we generated double conditional mutants using TgPax2Cre, and found that as expected, both genes play roles in semicircular canal morphogenesis. Unexpectedly, these genes also appear to have redund...

These are consistent with proposals that Fgf10 expression in the developing sensory tissues is required to induce non-sensory development. To determine the otic epithelial functions of Fgf3 and Fgf10, we generated double conditional mutants using TgPax2Cre, and found that as expected, both genes play roles in semicircular canal morphogenesis. Unexpectedly, these genes also appear to have redund...

4294 Cell Cycle Volume 11 issue 23 A common hallmark of many fungal species is the capacity to undergo cellular morphogenesis programs, which, for fungal pathogens, play critical roles in sexual reproduction, nutrient acquisition and virulence. Fungal morphogenesis comprises a diversity of processes, ranging from spore germination and branching in filamentous fungi such as the pathogen Aspergil...

Many embryonic organs undergo branching morphogenesis to maximize their functional epithelial surface area. Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM). During branching morphogenesis, new branches form by "budding" or "clefting." Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied ...

extending and retracting numerous actin-rich protrusions during tubule morphogenesis. Interestingly, tubule morphogenesis fails in mutant embryos lacking tip cells and supports a role for tip cells during this phase of tubule development. Moreover, the tip cells make highly specific contacts with target tissues once tubule morphogenesis is complete and these persist during larval life, raising ...

Morphogenesis is the process that underpins the selforganised development and regeneration of biological systems. The ability to mimick morphogenesis in artificial systems has great potential for many engineering applications, including production of biological tissue, design of robust electronic systems and the co-ordination of parallel computing. Previous attempts to mimick these complex dyna...

Islets of Langerhans are microorgans scattered throughout the pancreas, and are responsible for synthesizing and secreting pancreatic hormones. While progress has recently been made concerning cell differentiation of the islets of Langerhans, the mechanism controlling islet morphogenesis is not known. It is thought that these islets are formed by mature cell association, first differentiating i...

Islets of Langerhans are microorgans scattered throughout the pancreas, and are responsible for synthesizing and secreting pancreatic hormones. While progress has recently been made concerning cell differentiation of the islets of Langerhans, the mechanism controlling islet morphogenesis is not known. It is thought that these islets are formed by mature cell association, first differentiating i...

Recent experimental work in lung morphogenesis has described an elegant pattern of branching phenomena. Two primary forms of branching have been identified: side branching and tip splitting. In our previous study of lung branching morphogenesis, we used a 4 variable partial differential equation (PDE), due to Meinhardt, as our mathematical model to describe the reaction and diffusion of morphog...

A plethora of computational models have been developed in recent decades to account for the morphogenesis complex biological fluid networks, such as capillary beds. Contemporary adaptation are based on optimization schemes where networks react and adapt vessel conductance toward given flow patterns. Recent numeric studies network morphogenesis, incorporating uptake metabolites by embedding tiss...