Septicemic Epizootica (SE) in livestock caused by bacterial infection of Pasteurella multocida. The serotype P. multocida Indonesia is the Asian B:2. objective this study to determine antibody responses cattle after vaccinating with local isolates Local isolate SE Vaccine. Ten female aged around one year used experiment. Cattle divided into 3 groups, Group A (n=4) vaccinated vaccines, B commerc...

The 42- and 19-kDa C-terminal fragments of merozoite surface protein 1 (MSP-1(42) and MSP-1(19), respectively) are both promising blood-stage vaccine candidate antigens. At present, it is not clear which of the two antigens will be more suitable for inclusion in a cocktail malaria vaccine. In the present study, we expressed the two C-terminal fragments of Plasmodium vivax MSP-1 (PvMSP-1) in an ...

The prototype J-LEAPS T cell vaccine for HER-2/neu breast cancer (J-HER) consists of the murine HER-2/neu66-74 H-2d CD8 T cell epitope covalently attached through a triglycine linker to the J-immune cell binding ligand (ICBL) (human β2 microglobulin38-50 peptide). The J-ICBL was chosen for its potential to promote Th1/Tc1 responses. In this proof-of-concept study, the ability of J-HER to preven...

Background: Ticks and tick-borne diseases (TBDs) are considered to be the most serious health problems for animals humans. This issue prompts veterinarians researchers adopt better preventive control strategies. Therefore, this study aims develop hybridoma vaccine against Hylomma dromedarii infesting Camelus dromedaries. Methods: Myeloma cell culture was administered immunized mouse in order pr...

Wilms' tumor (WT1) protein is one of the most promising target antigens for cancer immunotherapy. In fact, clinical responses, such as growth stabilization or shrinkage of tumor with immunological responses, have been reported in patients vaccinated with WT1 peptide. Here, we performed WT1 peptide-based immunotherapy for a patient with chemotherapy-resistant salivary gland cancer, whose histolo...

BACKGROUND Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila) is an obligate intracellular bacterium causing the disease tick-borne fever (TBF) in domestic ruminants. An effective vaccine against the infection has been demanded for livestock by sheep farmers and veterinary practitioners for years. FINDINGS In the present study, we immunized lambs with an inactivated suspension of 1...

Aotus lemurinus monkeys were immunized with pools of either lipid-tailed peptides injected in PBS or peptides in Montanide ISA-51, all derived from four Plasmodium falciparum pre-erythrocytic antigens, namely, LSA1, LSA3, SALSA, and STARP. These formulations were well tolerated. Their immunogenicity was demonstrated by the induction of both B- and T-cell responses to most of the peptides studie...