Introduction Intake of broccoli sprouts, a rich source of the glucosinolate glucoraphanin, has been associated with decreased incidence, multiplicity, and tumor growth in animal cancer models.1-3 In 1992, Paul Talalay, MD, and colleagues at Johns Hopkins University identified the isothiocyanate, sulforaphane, a biologically active metabolite of glucoraphanin, as the compound in broccoli respons...

Description Medium chain triglycerides (MCTs) are a class of lipids in which three saturated fats are bound to a glycerol backbone. What distinguishes MCTs from other triglycerides is the fact that each fat molecule is between six and twelve carbons in length. MCTs are a component of many foods, with coconut and palm oils being the dietary sources with the highest concentration of MCTs. MCTs ar...

Introduction Docosahexaenoic acid (DHA) is an omega-3 fatty acid that falls into the larger category of polyunsaturated fatty acids (PUFAs). Although many chronic conditions are associated with excessive intake of dietary saturated and trans fatty acids (including obesity, insulin resistance, coronary heart disease, and some forms of cancer), research shows omega-3 fatty acids, including DHA, a...

Few breast cancer patients present with metastatic disease at the initial diagnosis. However, approximately one-quarter of patients with lymph node–negative disease and one half of patients with lymph node–positive tumors will ultimately develop distant recurrent breast cancer. Standard treatment of metastatic breast cancer generally includes systemic treatment and surgery or radiation as neede...

Modified Citrus Pectin Introduction Modified citrus pectin (MCP), also known as fractionated pectin, is a complex polysaccharide obtained from the peel and pulp of citrus fruits. Modified citrus pectin is rich in galactoside residues, giving it an affinity for certain types of cancer cells. Metastasis is one of the most life-threatening aspects of cancer and the lack of effective anti-metastati...

Review of the monograph: I. O. Demuz. Intellectual biography Petro Yanuarovych Stebnytskyi (1862‒1923) – public figure, book publisher, publicist: monograph. Pereyaslav (Kyiv region): Dombrovska Ya. M., 2022. 356 pp. ISBN 978-617-7747-62-7

Introduction Methylsulfonylmethane (MSM), also known as dimethyl sulfone (DMSO 2 ) and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals including humans. A white, odorless, slightly bitter-tasting crystalline substance containing 34-percent elemental sulfur, MSM is a normal oxidative metabolite product of dime...

Acute myelogenous leukemia (AML), although a relatively rare cancer, is the most common form of acute leukemia to occur in adults. The diagnosis and treatment of patients with AML has traditionally been based on cytogenetic prognostic markers. However, significant advancements in the discovery of the numerous molecular, cytogenetic, and biologic factors affecting this disease have revealed clea...

Introduction Coenzyme Q10 (CoQ10) is a compound found naturally in virtually every cell in the human body. Because of its ubiquitous presence in nature and its quinone structure (similar to that of vitamin K), CoQ10 is also known as ubiquinone. CoQ10 is a fat-soluble substance whose primary role is as a vital intermediate of the electron transport system in the mitochondria. Adequate amounts of...

Biochemistry and Pharmacokinetics Thiamine functions as a coenzyme in more than 24 enzymes, most importantly pyruvate dehydrogenase (for energy production in the Krebs cycle), transketolase (for lipid and glucose metabolism, production of branched chain amino acids, and production and maintenance of myelin sheath), and 2-oxo-glucarate dehydrogenase (for synthesis of acetylcholine, GABA, and glu...