نتایج جستجو برای: monoclonal antibodies
تعداد نتایج: 180227 فیلتر نتایج به سال:
Background and Objectives: Rituximab is an anti-CD20 chimeric monoclonal antibody widely used for the treatment of malignant B cells lymphoma. However, the immunogenicity of murine-derived monoclonal antibodies and the large size of full length antibodies restrict cancer immunotherapy. Humanized single chain antibodies can be a solution and a promising alternative for application in immunothera...
هدف از تحقیق حاضر، سنتز و بررسی اتصال نانوذرات مغناطیسی مگنتیت سوپرپارا مغناطیس با پوشش دکستران به آنتی بادی مونوکلونال بوده است.دراین ارتباط نانوذرات مگنتیت خالص (fe3o4) و جایگزین شده با یونzn+2 جهت بدست آمدن ترکیب (zn0.2fe2. 8o4) توسط روش هم رسوبی تحت شرایط معین سنتز گردید. متعاقباً آنتی بادی مونوکلونال هرسپتین که یک آنتی بادی علیه گیرنده her2 (جهت شناسایی سرطان سینه) می باشد، به ذرات سنتز شده...
virulence of the opportunistic yeast, candida albieans, involves the interplay of many complex changes including the yeast-hyphae transition, which mainly involves protein changes. cell wall mannoproteins are found to be the main cause of adherence of c. albieans to epithel ial cells in the first step of an infection process. in the present study, cell wall mannoproteins of intact yeast were pu...
background: different methods have been used for characterization of leishmania promastigotes. monoclonal antibodies are useful in characterization of leishmania spp . both amastogotes and promastigotes. objective: comparing the characterization of leishmania spp. promastigotes with immunoperoxidase test (avidin-biotin) techniques and an indirect immunofluorescent assay (ifa). methods: ap...
In recent years, there have been significant advancements in cancer treatment, particularly with the use of Monoclonal Antibodies (mAbs). These targeted therapies shown promise managing different types fewer side effects due to their high specificity. They become a predominant category newly developed drugs. antibodies offer diverse mechanisms action and can directly target cells while also boo...
ObjectiveTo review type 1 hypersensitivity reactions and anaphylaxis to checkpoint inhibitor–monoclonal antibodies its management with drug desensitization.Data SourcesEnglish-language literature on MEDLINE regarding hypersensitivity, anaphylaxis, antibodies.Study SelectionsReferences were selected based relevance, novelty, robustness, applicability.ResultsThere are well-known tissue toxicities...
*** Ruiz M, Cocores A, Tosti et al. Alopecia as an emerging adverse event to CGRP monoclonal antibodies: Cases Series, evaluation of FAERS, and literature review. Cephalalgia 2023. doi:10.1177/03331024221143538
a murine igm monoclonal antibody (ma-2c6) with κ-light chains directed against an antigenic determinant of outer surface protein a (ospa) of the lyme disease spirochete, borreliaburgdorferi, is produced. this antibody could bind specifically to ospa antigen of several isolates of b. burgdorferi, but not to the non-lyme disease bacteria such as t. pallidum and b. hermsii. antibody ma-2c6 was pur...
The hybridoma technique has been shown to be a most reproducible method for producing rodent monoclonal antibodies but poor results were obtained when it was used for generating human monoclonal antibodies. For immunotherapy, murine monoclonal antibodies are inadequate, whereas human monoclonal antibodies are virtually indispensable. Cellular, chemical, genetic and molecular methods to generate...
Anti-idiotype antisera were raised in syngeneic (BALB/c mice) and homologous (A/J mice) systems to study the cross-reactive idiotypes among monoclonal antibodies to PR8 and B/Lee virus HA and the expression of these idiotypes during primary and secondary antiviral responses of BALB/c mice. Extensive idiotypic cross-reactivity was demonstrated among monoclonal antibodies specific for distinct an...
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