نتایج جستجو برای: monoclonal
تعداد نتایج: 61302 فیلتر نتایج به سال:
A murine IgM monoclonal antibody (MA-2C6) with κ-light chains directed against an antigenic determinant of outer surface protein A (OspA) of the Lyme disease spirochete, Borreliaburgdorferi, is produced. This antibody could bind specifically to OspA antigen of several isolates of B. burgdorferi, but not to the non-Lyme disease bacteria such as T. pallidum and B. hermsii. Antibody MA-2C6 was pur...
Background: Monoclonal antibody technology allows identification of amastigote-specific antigen in human tissue biopsies and search for a suitable vaccine candidate, which may induce a long lasting immunity. Objectives: Production and partial characterization of seven monoclonal antibodies against Leishmania tropica promstigotes. Methods: Seven murine monoclonal antibodies of the IgG isotype we...
Background: Human cancer cell lines express human choriogonadotropin (hCG), its subunits and derivatives, regardless of their origin and type. It appears that hCG is a common phenotype in human cancer cell lines. In this research, the effects of hCG targeting monoclonal antibodies (7D9, T18H7 and T8B12) on human cancer cell lines were evaluated. Methods: Monoclonal antibody secreting hy...
Background and Objective: Lipoarabinomannan mannesylated (ManLAm) is one of the lipoglycans which forms a considerable percent of Mycobacterium Bovis BCG’ cellular wall. Considering that generation of monoclonal antibody against ManLAM antigen has many applications, specifically, in order to design the diagnostic kit for rapid diagnosing of tuberculosis, so the main objective of this study wa...
Abstract Background: Since the development of monoclonal antibodies by hybridoma technology the use of antibodies in targeted therapy has been considered. ScFv (single-chain variable fragment) is a small fragment of monoclonal antibody which binds to its target, especially. The goal of this study, is introducing of scFv, its production pathways as well as its diagnostic and therapeutic appl...
Bovine Viral Diarrhea virus (BVDV) is an important viral pathogen of cattle causing several clinical syndromes. There are usually no pathognomonic clinical signs of BVDV infection. Diagnostic investigations therefore rely on serological detection and virus isolation. Nonstructural protein 3 (NS3) as immunogenic protein of BVDV is genetically and antigenically conserved among different isolates....
Background & Aims: Toxoplasma gondii is an obligate, intracellular parasite, which is widely spread in the world. The parasite is able to infect all warm-blooded hosts including humans and farm animals. The infection in humans often occurs after the ingestion of raw or undercooked meat containing tissue cysts. Several methods have been applied to detect this parasite in contaminated foods. Reco...
Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...
Objetivo: Reportar un caso de gammapatía monoclonal significado indeterminado con eventos trombóticos y cardiovasculares mayores.
SARS-CoV-2 can escape natural immune responses, but the virus evade monoclonal antibodies and vaccine-mediated immunity?
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