Molecular mimicry manifests antagonistically with respect to the specificity of immune recognition. However, it often occurs because different Ags share surface topologies in terms of shape or chemical nature. It also occurs when a flexible paratope accommodates dissimilar Ags by adjusting structural features according to the antigenic epitopes or differential positioning in the Ag combining si...

The rheumatic heart disease (RHD) is beleived as a major menance in developing countries. There are many diagnostic methods available for detection of RHD. But these methods have several disadvantages like in term of sensitivity, selectivity, cost, so it is very important to develop a fast, sensitive, cheap device, which can easily available for RHD diagnosis. The major challenge is to find the...

Findings published in Sci Transl Med. 2013 Dec 18;5(216):216ra176 by De la Herrán-Arita et al. suggesting that hypocretin/orexin itself was an auto-antigen recognized by CD4 T cells in narcolepsy were recently withdrawn. Similarly, findings that molecular mimicry with specific sequences of pH1N1 had occurred have not been successfully confirmed. As a result, the Sci Transl Med. paper was withdr...

Protein-protein interactions mediate a vast number of cellular processes. Here, we present a regulatory mechanism in protein-protein interactions mediated by finely tuned structural instability and coupled with molecular mimicry. We show that a set of type III secretion (TTS) autoinhibited homodimeric chaperones adopt a molten globule-like state that transiently exposes the substrate binding si...