background: leishmaniasis represents a major public health concern in tropical and sub-tropical countries. at present, there is no efficacious vaccine against the disease and new control methods are needed. one way to access this important goal is to knock out genes of specific macromolecules to evaluate the effect of deletion on the growth, multiplication, pathogenesis and immunity of the para...

Molecular Simulation Investigations In article number 2206382, Mao Wang and Jianwen Jiang design a nanofluidic diode based on hybrid-bilayer covalent organic framework. Through molecular simulation, remarkable behavior is observed. Further analysis reveals that the synergistic effect of counterions in nanopore has positive impact rectification.

Whereas most G-protein-coupled receptors (GPCRs) are monomeric in structure, y-Aminobutyric acid type B (GABAb) receptors are heterodimers of two seven transmembrane protein subunits, GABAB(i) and GABAB(2>. GABAb receptor function is dependent upon the co-expression of both these proteins which, when individually expressed, are devoid of receptor activity. Desensitisation of cell surface recept...

BACKGROUND Free-standing carbon nanomembranes (CNM) with molecular thickness and macroscopic size are fascinating objects both for fundamental reasons and for applications in nanotechnology. Although being made from simple and identical precursors their internal structure is not fully known and hard to simulate due to the large system size that is necessary to draw definite conclusions. RESUL...

This paper describes our present strategy for the investigation of respiratory chain disorders in humans. Because very few of the underlying mutations causing mitochondrial disorders in humans are currently known, biochemical studies constitute a major tool in screening procedures for respiratory chain deficiencies. All biochemical and molecular methods described are scaled-down methods, allowi...

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 INVESTIGATIONS INTO MOLECULAR BEAM EPITAXIAL GROWTH OF INAS/GASB SUPERLATTICES by Lee Michael Murray A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Physics in the Graduate Coll...

The enzyme horseradish peroxidase (HRP) shows a decreasing activity when the enzyme's substrate hydrogen peroxide is present with the degree of inactivation being dependent on the incubation time and the hydrogen peroxide concentration. Incubation times of some minutes do not inactivate the enzyme independent of the H2O2 concentration. After several hours, only 50% of the activity is found for ...

OBJECTIVES DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences. METHODS Analysis of the pattern of short DNA repeats of the Thy-1 sequence with and without SNP. Searching for DNA-binding factors in any reg...