even when the effects of socioeconomic and behavioral factors—such as income, education, adequacy of prenatal care and harmful habits—are taken into account.5 In addition, despite the wide selection of safe and effective contraceptive methods and extensive dissemination of contraceptive information, unwanted pregnancy remains an important U. S. public health problem. More than half of the six m...

Underand over-nutrition during pregnancy has been linked to the later development of diseases such as diabetes and obesity. Epigenetic modifications may be one mechanism by which exposure to an altered intrauterine milieu or metabolic perturbation may influence the phenotype of the organism much later in life. Epigenetic modifications of the genome provide a mechanism that allows the stable pro...

We present a measurement of the electron spectrum from inclusive semileptonic B decay, using 5.1 fb−1 of Υ(4S) data collected with the Belle detector. A high-momentum lepton tag was used to separate the semileptonic B decay electrons from secondary decay electrons. We obtained the branching fraction, B(B → Xe+ν) = (10.90 ± 0.12 ± 0.49)%, with minimal model dependence. From this measurement, we ...

A new series of 4-aryl-1, 4-dihyropyridines possessing potent calcium channel blocking activity along with good vasodilatory profile by the modified Hantzsch condensation using trifluoroacetic acid as catalyst has been synthesized and reported from our laboratory. The present work describes chemo enzymatic approach for the enantioselective hydrolysis of a 1, 4dihydropyridine skeleton. In this s...

Heart failure (HF) is a debilitating cardiac syndrome characterized by dyspnea, poor exercise tolerance, and chronic fatigue along with high morbidity and mortality. Heart failure may be defined as the pathophysiologic state in which the heart is incapable of pumping a sufficient supply of blood to meet the metabolic requirements of the body or requires elevated ventricular filling pressures to...