1. Abstract 2. Introduction 2.1. HPV infection and carcinogenesis 2.2. Major transforming activities 2.3. The HPV life cycle 3. Section 3. The HPV E7 protein 3.1. Cellular targets of HPV E7 proteins: the retinoblastoma protein family 3.2. Cellular targets of HPV E7 proteins: cyclin-dependent kinase inhibitors 3.3. Cellular targets of HPV E7 proteins: chromatin modifying factors 4. Section 4. Th...

Clinical case We present a case of 17-year old girl with bronchial asthma, hospitalized in the clinic multiple times, despite high dose of combined corticosteroids as a controller medication. The child starts to show protest behavior towards therapy, that’s modifying in the course of psychological maturation – denial of the medicines, unhealthy and hazardous life styles. At the age of 16-years ...

Several aspects of mathematical astrobiology are discussed. It is argued that around the time of the origin of life the handedness of biomolecules must have established itself through an instability. Possible pathways of producing a certain handedness include mechanisms involving either autocatalysis or, alternatively, epimerization as governing effects. Concepts for establishing hereditary inf...

The most common chronic arthritis in rheumatology is rheumatoid arthritis (RA), which can affect between 0.5%-1% of the population (1). In addition to causing years of pain and disability, it also decreases life expectancy by an average of about a decade (2). The last 2 decades have witnessed early and intensive use of potent disease-modifying anti-rheumatic drugs, such as methotrexate and tumo...

Locomotor activity in many species undergoes pronounced alterations in early postnatal life, and environmental cues may be responsible for modifying this process. To determine how these events are reflected in the nervous system, we studied rats reared under two different conditions-the presence or absence of gravity-in which the performance of motor operations differed. We found a significant ...

life style is a blend of behavioral and personal habits and encompasses different aspects like nutrition, physical activity, stress, tobacco consumption and sleeping quality which is resulted from socialization process. regarding performed investigations, people with appropriate lifestyle are healthier, and this issue is more important for military forces which must have a higher level of physi...