Accurate retrieval of particulate backscattering coefficients has been a great challenge in optically complex Case 2 waters. Although several models exist for retrieval of the Inherent Optical Properties (IOP’s) such as particulate backscattering (bbp) from the remote sensing reflectance, these models produce bbp with high errors mainly because of improper parameterization or inappropriate defi...

Evolutionary trees sit at the core of all realistic models describing a set of related sequences, including alignment, homology search, ancestral protein reconstruction and 2D/3D structural change. It is important to assess the stochastic error when estimating a tree, including models using the most realistic likelihood-based optimizations, yet computation times may be many days or weeks. If so...

BACKGROUND The pore-forming subunit of the cardiac sodium channel, Na v1.5, has been previously found to be mutated in genetically determined arrhythmias. Na v1.5 associates with many proteins that regulate its function and cellular localisation. In order to identify more in situ Na v1.5 interacting proteins, genetically-modified mice with a high-affinity epitope in the sequence of Na v1.5 can ...

The pore-forming subunit of the cardiac sodium channel, Na 1.5, Background: has been previously found to be mutated in genetically determined arrhythmias. Na 1.5 associates with many proteins that regulate its function and cellular localisation. In order to identify more Na 1.5 interacting proteins, in situ genetically-modified mice with a high-affinity epitope in the sequence of Na 1.5 can be ...

Action potential (AP) profiles vary based on the cell type, with cells of the same type typically producing APs with similar shapes. But in certain syncytial tissues, such as the smooth muscle of the urinary bladder wall, even a single cell is known to exhibit APs with diverse profiles. The origin of this diversity is not currently understood, but is often attributed to factors such as syncytia...

To be effective for cytoplasmic delivery of therapeutics, nanoparticles (NPs) taken up via endocytic pathways must efficiently transport across the cell membrane and subsequently escape from the secondary endosomes. We hypothesized that the biomechanical and thermodynamic interactions of NPs with plasma and endosomal membrane lipids are involved in these processes. Using model plasma and endoso...

INTRODUCTION Pregnancy induced hypertension (PIH), especially preeclampsia, is a state of extremely increased oxidative stress (OS), due to decrease of antioxidant capacity in comparison to normotensive pregnant women. The consequences of increased state of oxidative stress with hypertension disorder in pregnancy are disorder of placental blood flow, intrauterine hypoxia of the fetus and distur...

Objective: Evaluating the effect of antenatal betamethasone on the biophysical profile and Doppler indices of umbilical and middle cerebral arteries. Materials and Methods: Twenty-five preterm labor singleton pregnancies (gestational age, 26-34 weeks) were studied prospectively. These patients received two consecutive doses of betamethasone 24 hours apart to accelerate pulmonary maturation. Fet...