Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms and are promising candidates to treat infections caused by pathogenic bacteria to animals and humans. AMPs also display anticancer activities because of their ability to inactivate a wide range of cancer cells. Cancer remains a cause of high morbidity and mortality worldwide. Therefore, the developme...

HSAF is an antifungal natural product with a new mode of action. A rare bacterial iterative PKS-NRPS assembles the HSAF skeleton. The biochemical characterization of the NRPS revealed that the thioesterase (TE) domain possesses the activities of both a protease and a peptide ligase. Active site mutagenesis, circular dichroism spectra, and homology modeling of the TE structure suggested that the...

The aim of a multi-mode resource-constrained project scheduling problem (MRCPSP) is to assign resource(s) with the restricted capacity to an execution mode of activities by considering relationship constraints, to achieve pre-determined objective(s). These goals vary with managers or decision makers of any organization who should determine suitable objective(s) considering organization strategi...

This research uses transaction cost theory to investigate IT outsourcing, allowing for intermediate modes of outsourcing. Results suggest that the governance mode chosen by firms to govern their IT activities is guided by cost-minimization considerations. The major transactional determinant of the governance mode choice is the need for technical and/or organization skills. This constitutes a st...

This paper presents a multi-mode resource-constrained project scheduling problem (MRCPSP) with maximizing the net present value (NPV) form the project contractor’s point of view. Positive and negative cash flows are considered in this model. Furthermore, to make the model close to the real situations, four different models for positive cash flows are considered. Two meta-heuristics, called simu...

the aim of a multi-mode resource-constrained project scheduling problem (mrcpsp) is to assign resource(s) with the restricted capacity to an execution mode of activities by considering relationship constraints, to achieve pre-determined objective(s). these goals vary with managers or decision makers of any organization who should determine suitable objective(s) considering organization strategi...

the goal of this research is the derivation of method for evaluation of efficiency improvement potential for district heating systems with focus on variable speed centrifugal pump. the effectiveness of the usage of the proportional pressure control is compared with the constant pressure control. this is why, energy calculation analyses have been realized for variable speed centrifugal pumps, an...

in this study, we present a mrcpsp/max (multi-mode resource-constrained project scheduling problem with minimum and maximum time lags) model with minimization tardiness costs and maximization earliness rewards of activities as objective. the proposed model is nearby to real-world problems and has wide applications in various projects. this problem is not available in the literature exactly and ...

abstract focusing on geographic and environmental factors, this article discusses recent recurring shifts in the mode of subsistence – from transhumant to sedentary pastoralism – observed among the bakhtiaris of central zagros. the article suggests that the evolutionary changes have been part of an adaptation strategy followed by bakhtiari communities in the face of new environmental conditions...

Although recent vertebrate studies have revealed that different spinal networks are recruited in locomotor mode- and speed-dependent manners, it is unknown whether humans share similar neural mechanisms. Here, we tested whether speed- and mode-dependence in the recruitment of human locomotor networks exists or not by statistically extracting locomotor networks. From electromyographic activity d...