Intramyocardial injection of bone marrow mononuclear cells (MNCs) with hyaluronan (HA) hydrogel is beneficial to the ischemic heart in a rat model of myocardial infarction (MI). However, the therapeutic efficacy and safety must be addressed in large animals before moving onto a clinical trial. Therefore, the effect of combined treatment on MI was investigated in pigs. Coronary artery ligation w...

OBJECTIVES To investigate the effects of human umbilical cord blood-derived mononuclear cell (hUCB-MNC) transplantation on pulmonary hypertension (PH) induced by monocrotaline (MCT) in immunodeficient mice and their distribution. METHODS MCT was administered to BALB/c Slc-nu/nu mice, and PH was induced in mice 4 weeks later. Fresh hUCB-MNCs harvested from a human donor after her delivery were...

Objective: To evaluate the influence of external knowledge absorbed on potential to innovate multinational companies (MNCs), in genetically modified (GM) seed sector from 2000 2018. Method: A quantitative approach was applied. Data composed main patents filed by MNCs GM sector, collected Espacenet database, MNCs’ annual reports, and INPI database. Variables were analyzed using panel regression ...

Using panel data of 1080 multinational corporations (MNCs) from the United States, we examine effects environmental sustainability practices on degree firms’ offshoring activities. In addition, disaggregate activities into their core components depending whether or not firm buys (inputs) sells (outputs) and/or owns assets in a given country and extent to which influence different decisions. The...

Magnocellular neurosecretory cells (MNCs), of the paraventricular and supraoptic nuclei of the hypothalamus, secrete the hormones vasopressin and oxytocin. As a result, they have an essential role in fundamental physiological responses including regulation of blood volume and fluid homeostasis. C-type natriuretic peptide (CNP) is present at high levels in the hypothalamus. Although CNP is known...

Tendon-like tissue generated from stem cells in vitro has the potential to replace tendons and ligaments lost through injury and disease. However, thus far, no information has been available on the mechanism of tendon formation in vitro and how to accelerate the process. We show here that human mesenchymal stem cells (MSCs) and bone marrow-derived mononuclear cells (BM-MNCs) can generate tendon...

Chakfe, Yassar, Zizhen Zhang and Charles W. Bourque. IL-1 directly excites isolated rat supraoptic neurons via upregulation of the osmosensory cation current. Am J Physiol Regul Integr Comp Physiol 290: R1183–R1190, 2006. First published November 17, 2005; doi:10.1152/ajpregu.00716.2005.—Previous studies have shown that IL-1 can excite the magnocellular neurosecretory cells (MNCs) of the hypoth...

Previous studies have shown that interleukin-1β (IL-1β) can excite the magnocellular neurosecretory cells (MNCs) of the hypothalamus. However it is not known if IL-1β can have direct IL-1 receptor type 1 (IL-1R1)-mediated effects on MNCs, and little is known about the cellular mechanisms by which IL-1β influences electrical activity in these cells. Here we used patch-clamp recordings to examine...

We analyzed the effect of hypertension on postischemic vasculogenesis. Ischemia was induced by right femoral artery ligature in Wistar Kyoto rats (WKY) or spontaneously hypertensive rats (SHR) treated with or without angiotensin-converting enzyme inhibitor (Perindopril, 0.76 mg/kg/d) and angiotensin type 1 receptor blocker (losartan, 30 mg/kg/d). Basal postischemic neovascularization was reduce...

The immunomodulatory effects of liposomal amphotericin B (LAMB), amphotericin B lipid complex, and amphotericin B colloidal dispersion (ABCD) on antifungal activity of human monocytes (MNCs), an important component of antifungal host defense, against Aspergillus fumigatus were compared to those of deoxycholate amphotericin B (DAMB). MNCs from healthy volunteers were incubated with 1 or 5 microg...